Neural predictors of gait stability when walking freely in the real-world

Journal of Neuroengineering and Rehabilitation
Sara PizzamiglioDuncan L Turner

Abstract

Gait impairments during real-world locomotion are common in neurological diseases. However, very little is currently known about the neural correlates of walking in the real world and on which regions of the brain are involved in regulating gait stability and performance. As a first step to understanding how neural control of gait may be impaired in neurological conditions such as Parkinson's disease, we investigated how regional brain activation might predict walking performance in the urban environment and whilst engaging with secondary tasks in healthy subjects. We recorded gait characteristics including trunk acceleration and brain activation in 14 healthy young subjects whilst they walked around the university campus freely (single task), while conversing with the experimenter and while texting with their smartphone. Neural spectral power density (PSD) was evaluated in three brain regions of interest, namely the pre-frontal cortex (PFC) and bilateral posterior parietal cortex (right/left PPC). We hypothesized that specific regional neural activation would predict trunk acceleration data obtained during the different walking conditions. Vertical trunk acceleration was predicted by gait velocity and left PPC theta (4-7 Hz) b...Continue Reading

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Citations

Jun 9, 2019·Journal of Neuroengineering and Rehabilitation·Rocco Salvatore CalabròPlacido Bramanti
Sep 11, 2020·The European Journal of Neuroscience·Nadine Svenja Josée JacobsenStefan Debener
Nov 15, 2020·Mechanisms of Ageing and Development·Gianmaria MancioppiFilippo Cavallo
Jul 10, 2021·Scientific Reports·Maria RubegaAlessandra Del Felice
Sep 11, 2021·Neurorehabilitation and Neural Repair·Samuel StuartMartina Mancini

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Software Mentioned

EEGLab
MatLab
SPSS
iGAIT
AndroSensor
MOBI

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