Neural regulation in tooth regeneration of Ambystoma mexicanum.

Scientific Reports
Aki MakanaeAkira Satoh

Abstract

The presence of nerves is an important factor in successful organ regeneration in amphibians. The Mexican salamander, Ambystoma mexicanum, is able to regenerate limbs, tail, and gills when nerves are present. However, the nerve-dependency of tooth regeneration has not been evaluated. Here, we reevaluated tooth regeneration processes in axolotls using a three-dimensional reconstitution method called CoMBI and found that tooth regeneration is nerve-dependent although the dentary bone is independent of nerve presence. The induction and invagination of the dental lamina were delayed by denervation. Exogenous Fgf2, Fgf8, and Bmp7 expression could induce tooth placodes even in the denervated mandible. Our results suggest that the role of nerves is conserved and that Fgf+Bmp signals play key roles in axolotl organ-level regeneration. The presence of nerves is an important factor in successful organ regeneration in amphibians. The Mexican salamander, Ambystoma mexicanum, is able to regenerate limbs, tail, and gills when nerves are present. However, the nervedependency of tooth regeneration has not been evaluated. Here, we reevaluated tooth regeneration processes in axolotls using a three-dimensional reconstitution method called CoMBI a...Continue Reading

References

Jul 1, 1974·The Journal of Experimental Zoology·H T Graver
Jan 1, 1971·Zeitschrift für Zellforschung und mikroskopische Anatomie·M M Smith, A E Miles
Sep 1, 1994·Developmental Biology·F Tuisku, C Hildebrand
Jan 26, 1996·Biochemical and Biophysical Research Communications·S IsekiS Noji
Jan 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Holly L D NyeDavid L Stocum
Jun 13, 2003·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Joachim WistubaGünter Clemen
Nov 1, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Akira SatohHiroyuki Ide
Feb 23, 2007·Biological Reviews of the Cambridge Philosophical Society·Tiphaine Davit-BéalJean-Yves Sire
Mar 14, 2007·The Biochemical Journal·Li ZhengMisako Nakashima
Jul 23, 2008·Current Opinion in Genetics & Development·Viravuth P Yin, Kenneth D Poss
Sep 20, 2012·Trends in Neurosciences·Anoop Kumar, Jeremy P Brockes
Jun 19, 2013·Developmental Biology·Aki MakanaeAkira Satoh
Jun 24, 2015·Development, Growth & Differentiation·Akira SatohAki Makanae
Sep 1, 1979·Wilhelm Roux's Archives of Developmental Biology·Günter Clemen
Jan 3, 2018·Developmental Biology·Kazumasa MitogawaAkira Satoh
Nov 1, 2018·The International Journal of Developmental Biology·Akira SatohAki Makanae
Feb 7, 2019·Nature Communications·Ling YuKen Muneoka
Apr 30, 2019·Developmental Biology·Nanami SaitoAkira Satoh

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Citations

Aug 14, 2021·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Sakiya YamamotoAkira Satoh

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Methods Mentioned

BETA
transgenic
amputation
dissection

Software Mentioned

Amira

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