PMID: 7083024Apr 22, 1982Paper

Neural regulation of adrenal chromaffin cell function in the mouse--stress effect on the distribution of [3H]dopamine in denervated adrenal medulla

Brain Research
T Hirano

Abstract

Effects of adrenal denervation and stress on the distribution of radioactivity in the adrenal medulla after [3H]dopamine injection was studied by light microscopic autoradiography. Denervation of the adrenal gland abolished the stress (restraint plus water immersion) induced degranulation of adrenal chromaffin cells and decreased uptake of [3H]dopamine. Denervated chromaffin cell of stress mice incorporated as high radioactivity as those of no stress mice. Adrenal denervation increased the uptake in adrenaline-storing (A) cells but not in noradrenaline-storing (NA) cells. The characteristic distribution of radioactivity (high radioactivity along the cortico-medullary junction) was reinforced by adrenal denervation. Under stress conditions, increase in pituitary adrenocortical system did not enhance the uptake of [3H]dopamine in chromaffin cell while increase in nerve activity suppressed the uptake. Spontaneous activity of the splanchnic nerve to adrenal chromaffin cells suppresses the uptake of [3H]dopamine. The neural influence is stronger on A cells than on NA cells. Chromaffin cells in the subcortical zone are more intensely controlled by the neural influence than those in the central zone.

References

Jul 1, 1979·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·S Kobayashi, Y Serizawa
May 1, 1980·Journal of the Autonomic Nervous System·T Hirano, A Niijima
Dec 1, 1952·British Journal of Pharmacology and Chemotherapy·A S OUTSCHOORN
Apr 1, 1964·Chemical & Pharmaceutical Bulletin·K TAKAGIK WATANABE
Sep 1, 1950·British Journal of Pharmacology and Chemotherapy·J H BURNR H O PARKER
Oct 1, 1978·Neuroscience Letters·T Hirano, S Kobayashi

Citations

Jan 1, 1988·Experimental Brain Research·M Jousselin-Hosaja
Jan 1, 1984·Journal of Neural Transmission·T ImahayashiH S Ozaki
Oct 1, 1989·Journal of the Autonomic Nervous System·T HiranoA Niijima
Jan 1, 1991·Journal of the Autonomic Nervous System·T HiranoA Niijima
Jul 1, 1982·Neuroscience·J H Phillips

Related Concepts

Adrenal Medulla
Autoradiography
Chromaffin Granule
Chromaffin System
Intropin
Argentaffin Cell
Medihaler-Epi
Muridae
Norepinephrine, (+, -)-Isomer

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