PMID: 7083024Apr 22, 1982Paper

Neural regulation of adrenal chromaffin cell function in the mouse--stress effect on the distribution of [3H]dopamine in denervated adrenal medulla

Brain Research
T Hirano


Effects of adrenal denervation and stress on the distribution of radioactivity in the adrenal medulla after [3H]dopamine injection was studied by light microscopic autoradiography. Denervation of the adrenal gland abolished the stress (restraint plus water immersion) induced degranulation of adrenal chromaffin cells and decreased uptake of [3H]dopamine. Denervated chromaffin cell of stress mice incorporated as high radioactivity as those of no stress mice. Adrenal denervation increased the uptake in adrenaline-storing (A) cells but not in noradrenaline-storing (NA) cells. The characteristic distribution of radioactivity (high radioactivity along the cortico-medullary junction) was reinforced by adrenal denervation. Under stress conditions, increase in pituitary adrenocortical system did not enhance the uptake of [3H]dopamine in chromaffin cell while increase in nerve activity suppressed the uptake. Spontaneous activity of the splanchnic nerve to adrenal chromaffin cells suppresses the uptake of [3H]dopamine. The neural influence is stronger on A cells than on NA cells. Chromaffin cells in the subcortical zone are more intensely controlled by the neural influence than those in the central zone.


Jul 1, 1979·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·S Kobayashi, Y Serizawa
May 1, 1980·Journal of the Autonomic Nervous System·T Hirano, A Niijima
Dec 1, 1952·British Journal of Pharmacology and Chemotherapy·A S OUTSCHOORN
Apr 1, 1964·Chemical & Pharmaceutical Bulletin·K TAKAGIK WATANABE
Sep 1, 1950·British Journal of Pharmacology and Chemotherapy·J H BURNR H O PARKER
Oct 1, 1978·Neuroscience Letters·T Hirano, S Kobayashi


Jan 1, 1988·Experimental Brain Research·M Jousselin-Hosaja
Jan 1, 1984·Journal of Neural Transmission·T ImahayashiH S Ozaki
Oct 1, 1989·Journal of the Autonomic Nervous System·T HiranoA Niijima
Jan 1, 1991·Journal of the Autonomic Nervous System·T HiranoA Niijima
Jul 1, 1982·Neuroscience·J H Phillips

Related Concepts

Adrenal Medulla
Chromaffin Granule
Chromaffin System
Argentaffin Cell
Norepinephrine, (+, -)-Isomer

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