Oct 20, 2006

Neural representations of temporally modulated signals in the auditory thalamus of awake primates

Journal of Neurophysiology
Edward L Bartlett, Xiaoqin Wang

Abstract

In sensory systems, the thalamus has historically been considered a relay station. Neural representations of temporal modulations in the auditory system undergo considerable changes as they pass from the inferior colliculus (IC) to the auditory cortex. We sought to determine in awake primates the extent to which auditory thalamic neurons contribute to these transformations. We tested the temporal processing capabilities of medial geniculate body (MGB) neurons in awake marmoset monkeys using repetitive click stimuli. MGB neurons were able to synchronize to periodic clicks at repetition rates significantly higher than auditory cortex neurons. Unlike responses in the MGB of anesthetized animals, >40% of MGB neurons in awake marmosets displayed nonsynchronized discharges when stimulated by high click rates (short interclick intervals). Such nonsynchronized MGB responses typically occurred at higher repetition rates than those observed in auditory cortex. In contrast to auditory cortex neurons, many MGB neurons exhibited both synchronized and nonsynchronized discharge patterns. In both MGB and auditory cortex, synchronized and nonsynchronized responses represented complementary ranges of interclick intervals (1/click rate). Furtherm...Continue Reading

  • References28
  • Citations66

References

  • References28
  • Citations66

Citations

Mentioned in this Paper

Biochemical Pathway
Vigilance, Cortical
Implantable Stimulation Electrodes
Neurons
Entire Auditory System
Cercopithecidae
Platyrrhini
Acoustic Stimulation
Inferior Colliculus
Data Interpretation, Statistical

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