PMID: 2791679Oct 1, 1989

Neural respiratory drive and neuromuscular coupling during CO2 rebreathing in patients with chronic interstitial lung disease

Chest
M GoriniG Scano

Abstract

In 12 patients with CILD and 18 age-matched normal subjects we assessed the ventilatory control system at three levels: (a) neural, as assessed by EMGd (XP/Ti) and EMGint muscles via surface electrodes; (b) muscular, as assessed by mouth occlusion pressure (P0.1); and (c) ventilatory, as assessed by both ventilation (VE) and the related parameters, tidal volume (VT) and respiratory frequency (f). Compared with a normal control group, patients exhibited a significant decrease in lung volumes and in MIP; VT and inspiratory time (Ti) were significantly lower, while VT/Ti, P0.1, and both EMGd and EMGint were significantly greater in patients. During a CO2 rebreathing test, patients exhibited significantly greater EMGd, EMGint, and P0.1 responses to increasing PETCO2 than the control group. VE response slopes were similar in the two groups. For a given EMGd response slope (delta XP/Ti/delta PETCO2), the average P0.1 response slope (delta P0.1/delta PETCO2) was found to be significantly lower in patients than in the normal control group. Compared with normal subjects, CILD patients have a normal or increased neural component of respiratory activity and relatively low neuromuscular coupling (delta P0.1/delta XP/Ti). The decreased neur...Continue Reading

References

Oct 1, 1982·Respiration Physiology·J G Martin, A De Troyer
Apr 1, 1983·The American Review of Respiratory Disease·A F DiMarcoB Gothe
Dec 1, 1982·Chest·M J Belman, G C Sieck
Dec 1, 1981·Clinical Science·J SavoyN R Anthonisen
Nov 1, 1980·Archives of Environmental Health·G ScanoR Sergysels

Citations

Sep 1, 1995·Respiratory Medicine·G J Gibson
Jun 1, 1992·The American Review of Respiratory Disease·A SpinelliG Scano
Apr 9, 2014·BMC Pulmonary Medicine·Maarten K NinaberJan Stolk
Jan 16, 2016·Chronic Respiratory Disease·Marios PanagiotouCharlie Strange
Jan 26, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Laurent PlantierBruno Crestani
Mar 29, 2019·Journal of Applied Physiology·Shigehiko Ogoh
Aug 29, 2017·PloS One·Claudia LlontopFrancisco García-Río
Jun 1, 1995·British Journal of Sports Medicine·S P McGurkM J Anderson
Jun 17, 2003·Journal of Applied Physiology·Francisco García-RíoJosé Villamor

Related Concepts

Surface Electromyography
Lung Volume Measurements
Pulmonary Fibrosis
Respiratory Function Tests
Respiratory Muscles
Respiratory Mechanics

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