Neural response to catecholamine depletion in remitted bulimia nervosa: Relation to depression and relapse

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Stefanie Verena MuellerGregor Hasler

Abstract

Bulimia nervosa has been associated with a dysregulated catecholamine system. Nevertheless, the influence of this dysregulation on bulimic symptoms, on neural activity, and on the course of the illness is not clear yet. An instructive paradigm for directly investigating the relationship between catecholaminergic functioning and bulimia nervosa has involved the behavioral and neural responses to experimental catecholamine depletion. The purpose of this study was to examine the neural substrate of catecholaminergic dysfunction in bulimia nervosa and its relationship to relapse. In a randomized, double-blind and crossover study design, catecholamine depletion was achieved by using the oral administration of alpha-methyl-paratyrosine (AMPT) over 24 h in 18 remitted bulimic (rBN) and 22 healthy (HC) female participants. Cerebral blood flow (CBF) was measured using a pseudo continuous arterial spin labeling (pCASL) sequence. In a follow-up telephone interview, bulimic relapse was assessed. Following AMPT, rBN participants revealed an increased vigor reduction and CBF decreases in the pallidum and posterior midcingulate cortex (pMCC) relative to HC participants showing no CBF changes in these regions. These results indicated that the ...Continue Reading

Citations

Nov 7, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stefanie Verena MuellerGregor Hasler
Apr 15, 2020·Scientific Reports·Yoan MihovGregor Hasler

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