Neural responses to emotional involuntary memories in posttraumatic stress disorder: Differences in timing and activity

NeuroImage. Clinical
Shana A HallDavid C Rubin

Abstract

Involuntary memories are a hallmark symptom of posttraumatic stress disorder (PTSD), but studies of the neural basis of involuntary memory retrieval in posttraumatic stress disorder (PTSD) are sparse. The study of the neural correlates of involuntary memories of stressful events in PTSD focuses on the voluntary retrieval of memories that are sometimes recalled as intrusive involuntary memories, not on involuntary retrieval while being scanned. Involuntary memory retrieval in controls has been shown to elicit activity in the parahippocampal gyrus, precuneus, inferior parietal cortex, and posterior midline regions. However, it is unknown whether involuntary memories are supported by the same mechanisms in PTSD. Because previous work has shown that both behavioral and neural responsivity is slowed in PTSD, we examined the spatiotemporal dynamics of the neural activity underlying negative and neutral involuntary memory retrieval. Twenty-one individuals with PTSD and 21 non-PTSD, trauma-exposed controls performed an involuntary memory task, while undergoing a functional magnetic resonance imaging scan. Environmental sounds served as cues for well-associated pictures of negative and neutral scenes. We used a finite impulse response m...Continue Reading

Citations

Aug 23, 2019·Chronic Stress·Lynn D SelemonDouglas E Williamson
Jun 13, 2020·Frontiers in Psychology·Annabelle StarckUlrich Stangier
Jul 28, 2019·Frontiers in Neuroendocrinology·Josep Moreno-Rius
Aug 29, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Renée M VisserEmily A Holmes

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Statistical Parametric Mapping SPM12
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