Neural Reward Processing Mediates the Relationship between Insomnia Symptoms and Depression in Adolescence

Sleep
Melynda D CasementErika E Forbes

Abstract

Emerging evidence suggests that insomnia may disrupt reward-related brain function-a potentially important factor in the development of depressive disorder. Adolescence may be a period during which such disruption is especially problematic given the rise in the incidence of insomnia and ongoing development of neural systems that support reward processing. The present study uses longitudinal data to test the hypothesis that disruption of neural reward processing is a mechanism by which insomnia symptoms-including nocturnal insomnia symptoms (NIS) and nonrestorative sleep (NRS)-contribute to depressive symptoms in adolescent girls. Participants were 123 adolescent girls and their caregivers from an ongoing longitudinal study of precursors to depression across adolescent development. NIS and NRS were assessed annually from ages 9 to 13 years. Girls completed a monetary reward task during a functional MRI scan at age 16 years. Depressive symptoms were assessed at ages 16 and 17 years. Multivariable regression tested the prospective associations between NIS and NRS, neural response during reward anticipation, and the mean number of depressive symptoms (omitting sleep problems). NRS, but not NIS, during early adolescence was positive...Continue Reading

References

May 1, 1996·Sleep·J J Pilcher, A I Huffcutt
Mar 1, 1997·Journal of Child Psychology and Psychiatry, and Allied Disciplines·M Kovacs
Dec 22, 1998·Brain Research. Brain Research Reviews·K C Berridge, T E Robinson
Dec 29, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·M M OhayonR G Priest
Jul 3, 2002·Nature Reviews. Neuroscience·Mark G Baxter, Elisabeth A Murray
Jul 20, 2002·Journal of Psychosomatic Research·Robert E RobertsIrene Ger Chen
Oct 11, 2003·Trends in Cognitive Sciences·Jonathan St B T Evans
Oct 31, 2003·The American Psychologist·Daniel Kahneman
Dec 17, 2004·Behavioral Sleep Medicine·Daniel J TaylorH Heith Durrence
Feb 3, 2005·Sleep·Jack D EdingerUNKNOWN American Academy of Sleep Medicine Work Group
Apr 6, 2005·NeuroImage·Thomas NicholsJean-Baptiste Poline
Sep 2, 2005·Nature Reviews. Neuroscience·Morten L Kringelbach
Sep 6, 2005·NeuroImage·Georg JuckelAndreas Heinz
Nov 2, 2005·The Journal of Clinical Psychiatry·Norifumi TsunoKaren Ritchie
Nov 3, 2005·Development and Psychopathology·Erika E Forbes, Ronald E Dahl
Nov 22, 2005·Pain·Monika Haack, Janet M Mullington
Mar 23, 2006·Nature Reviews. Neuroscience·David M Amodio, Chris D Frith
Sep 5, 2006·Biological Psychiatry·Anouk ScheresFrancisco Xavier Castellanos
Sep 19, 2006·Journal of Psychiatric Research·Eric O JohnsonNaomi Breslau
Jun 16, 2007·Neuroscience and Biobehavioral Reviews·Christopher G DaveyNicholas B Allen
Feb 16, 2008·Journal of Sleep Research·Peter L FranzenDaniel J Buysse
Mar 11, 2008·Trends in Neurosciences·Susan L Andersen, Martin H Teicher
Sep 22, 2009·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Stephanie M HolmRonald E Dahl
Feb 9, 2010·Sleep Medicine Reviews·Chiara BaglioniDieter Riemann
Mar 27, 2010·Sleep·Els van der HelmMatthew P Walker
Apr 17, 2010·Sleep·Thomas RothJohn L Werth
Jul 1, 2010·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Kate KeenanKathleen McTigue
Nov 10, 2010·Emotion·Lisa S TalbotAllison G Harvey
Dec 21, 2010·Trends in Cognitive Sciences·Amit EtkinRaffael Kalisch
Dec 28, 2010·Journal of Affective Disorders·Cédric LemognePhilippe Fossati
Feb 9, 2011·Journal of Affective Disorders·Chiara BaglioniDieter Riemann
Mar 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ninad GujarMatthew P Walker
Dec 16, 2011·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Rachel ManberJason C Ong
Mar 28, 2012·Journal of the American Academy of Child and Adolescent Psychiatry·Amy F T Arnsten, Katya Rubia
May 9, 2012·Sleep Medicine·Kate Wilkinson, Colin Shapiro
Dec 25, 2012·Journal of Affective Disorders·Robert E Roberts, Hao T Duong
Jan 5, 2013·Psychological Medicine·B C MullinP L Franzen

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Citations

Aug 2, 2017·Journal of the American Psychiatric Nurses Association·Jinwen ZhangShenghui Li
Feb 7, 2020·Psychological Medicine·Juan J Madrid-ValeroAlice M Gregory
Sep 25, 2020·Journal of Pediatric Psychology·Kaitlyn E BrodarMaria M Llabre
Jan 4, 2019·Journal of Child & Adolescent Trauma·Michelle Evans-ChaseElizabeth Pantesco
Jun 17, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chloe C BoyleMichael R Irwin
May 21, 2019·Frontiers in Psychology·Torhild Anita SørengaardIngvild Saksvik-Lehouillier
Aug 12, 2019·Journal of Affective Disorders·Shadi Bagherzadeh-AzbariMasoud Tahmasian
Jan 14, 2021·International Journal of Environmental Research and Public Health·Violeta Clement-CarbonellJuan J Madrid-Valero
Feb 13, 2021·Scientific Reports·Yuki MotomuraKazuo Mishima
Nov 17, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Sarah M InkelisRakesh Bhattacharjee
Jun 27, 2020·Behavior Therapy·Elaine M BolandPhilip R Gehrman
Feb 27, 2021·Psychological Medicine·Gabrielle I LiverantDiego A Pizzagalli
Oct 22, 2017·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Lindsay P BodellErika E Forbes
Oct 5, 2021·Sleep·Jiefan LingShirley Xin Li

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