Neural Sensing of Organ Volume

Trends in Neurosciences
Benjamin D Umans, Stephen D Liberles

Abstract

Many internal organs change volume periodically. For example, the stomach accommodates ingested food and drink, the bladder stores urine, the heart fills with blood, and the lungs expand with every breath. Specialized peripheral sensory neurons function as mechanoreceptors that detect tissue stretch to infer changes in organ volume and then relay this information to the brain. Central neural circuits process this information and evoke perceptions (satiety, nausea), control physiology (breathing, heart rate), and impact behavior (feeding, micturition). Yet, basic questions remain about how neurons sense organ distension and whether common sensory motifs are involved across organs. Here, we review candidate mechanosensory receptors, cell types, and neural circuits, focusing on the stomach, bladder, and airways. Understanding mechanisms of organ stretch sensation may provide new ways to treat autonomic dysfunction.

Citations

Sep 27, 2019·Toxicologic Pathology·LaTasha K Crawford, Michael J Caterina
Jul 1, 2020·Frontiers in Physiology·Yoko B WangAmanda J Page
Feb 20, 2020·Biomechanics and Modeling in Mechanobiology·Lingxia BaoHans Gregersen
Apr 13, 2019·Histochemistry and Cell Biology·Anne E TurcoChad M Vezina
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Simon VermeirenSimon Desiderio
Nov 21, 2019·Cell Reports·Nima Ghitani, Alexander T Chesler
Nov 21, 2019·Cell Reports·Soohong MinStephen D Liberles
Feb 19, 2021·ELife·Soohong MinStephen Liberles
Mar 19, 2020·Immunity·Coco ChuIsaac M Chiu
Sep 24, 2019·Cell·Jin ZhangCharles S Zuker
Jun 22, 2021·Annual Review of Biochemistry·Marcin SzczotAlexander T Chesler
Oct 5, 2021·Neurourology and Urodynamics·Claire C YangJanet R Keast

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