PMID: 7537358Feb 6, 1995Paper

Neural somatostatin, vasoactive intestinal polypeptide and substance P in canine and human jejunum

Neuroscience Letters
E A AcciliA M Buchan

Abstract

The distribution and co-localization of substance P immunoreactivity (SP-IR), somatostatin-IR (SS-IR) and vasoactive intestinal peptide-IR (VIP-IR) have been determined in canine and human jejunum by immunocytochemistry (ICC). Immunostaining with an antibody to protein gene product 9.5 revealed fewer neuronal cell bodies in the submucosal ganglion of human than in canine intestine. Double immunostaining demonstrated that SP-IR and SS-IR were always co-localized in human but never in canine submucosal neurons. In both species, VIP-IR was present in a separate population of neurons. In canine submucosal ganglia, each peptide represented approximately one-third of the neurons while the proportions of VIP and SP/SS-containing neurons in human were 40% and 42%, respectively. These results provide neuroanatomical evidence for different functions of neural SP and SS in canine and human jejunum.

References

Jun 1, 1990·Canadian Journal of Physiology and Pharmacology·A M BuchanE Accili
Jul 8, 1985·The Journal of Comparative Neurology·E E DanielJ R Keast
Jan 1, 1984·Cell and Tissue Research·J R KeastM Costa
Aug 1, 1993·Canadian Journal of Physiology and Pharmacology·E A AcciliA M Buchan

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Citations

Apr 22, 2006·Cell and Tissue Research·Daniel P PooleJohn B Furness
Mar 28, 2009·Cell and Tissue Research·Caterina Mongardi FantaguzziJohn B Furness
Jan 1, 1997·Mediators of Inflammation·J D van Bergeijk, J H Wilson
Nov 10, 2013·Histochemistry and Cell Biology·Nicholas BeuscherAxel Brehmer
Jan 5, 2002·Canadian Journal of Physiology and Pharmacology·V C SmithA M Buchan
Mar 19, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Andreas KustermannAxel Brehmer
Apr 18, 2006·Autonomic Neuroscience : Basic & Clinical·Alessandro LecciCarlo Alberto Maggi
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·J P LiW Y Chey
Oct 2, 2020·Animals : an Open Access Journal From MDPI·Andrzej RychlikKrystyna Makowska

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