Sep 1, 2011

Neural stem cell-based therapy for ischemic stroke

Translational Stroke Research
Zaal Kokaia, Vladimer Darsalia

Abstract

Stem cell-based approaches for the treatment of stroke have been the subject of intensive research over the past decade. Based on accumulated experimental evidence, stem cell-based therapy is a very promising prospect for the development of a novel treatment to restore stroke-damaged brain and impaired neurological function. Studies performed on experimental animal models of stroke employed a variety of stem cell types from diverse sources and have demonstrated their ability to replace lost neurons and functionally integrate into the brain, modulate inflammation, and stimulate angiogenesis and neurogenesis from an endogenous stem cell pool, most likely through trophic actions. A few clinical trials in stroke patients using stem cell transplantation have been completed or are on-going but the results have not yet proven the effectiveness of the stem cell-based approaches. A joint effort of stroke researchers and clinicians is needed to further optimize treatment protocols using safe and reproducible stem cell sources tested in relevant animal models of stroke and showing substantial neurological recovery of stroke-impaired function.

Mentioned in this Paper

Ischemic Cerebrovascular Accident
Angiogenic Process
Neurons
Brain
Tumor Angiogenesis
Neural Stem Cells
Encephalitis
Inflammation
Transplantation Aspects
Cerebral Infarction

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