Neural stem cell therapies and hypoxic-ischemic brain injury

Progress in Neurobiology
Lei Huang, Lubo Zhang

Abstract

Hypoxic-ischemic brain injury is a significant cause of morbidity and mortality in the adult as well as in the neonate. Extensive pre-clinical studies have shown promising therapeutic effects of neural stem cell-based treatments for hypoxic-ischemic brain injury. There are two major strategies of neural stem cell-based therapies: transplanting exogenous neural stem cells and boosting self-repair of endogenous neural stem cells. Neural stem cell transplantation has been proved to improve functional recovery after brain injury through multiple by-stander mechanisms (e.g., neuroprotection, immunomodulation), rather than simple cell-replacement. Endogenous neural stem cells reside in certain neurogenic niches of the brain and response to brain injury. Many molecules (e.g., neurotrophic factors) can stimulate or enhance proliferation and differentiation of endogenous neural stem cells after injury. In this review, we first present an overview of neural stem cells during normal brain development and the effect of hypoxic-ischemic injury on the activation and function of endogenous neural stem cells in the brain. We then summarize and discuss the current knowledge of strategies and mechanisms for neural stem cell-based therapies on br...Continue Reading

Citations

Jan 10, 2020·Stem Cells and Development·Tianqi TuYong Jiang
Aug 20, 2020·The Cochrane Database of Systematic Reviews·Matteo BruschettiniBernard Thébaud
Sep 6, 2020·Chinese Medical Journal·Cheng JiangHai-Jun Ren
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Oct 16, 2020·Journal of Stroke·Shuai ZhangXiaofeng Jia
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Jan 16, 2022·Translational Stroke Research·Tong ZhaoJianhong Zhu

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