Neural stem cells and cholinergic neurons: regulation by immunolesion and treatment with mitogens, retinoic acid, and nerve growth factor

Proceedings of the National Academy of Sciences of the United States of America
Laura CalzaLuciana Giardino

Abstract

Degenerative diseases represent a severe problem because of the very limited repair capability of the nervous system. To test the potential of using stem cells in the adult central nervous system as "brain-marrow" for repair purposes, several issues need to be clarified. We are exploring the possibility of influencing, in vivo, proliferation, migration, and phenotype lineage of stem cells in the brain of adult animals with selective neural lesions by exogenous administration (alone or in combination) of hormones, cytokines, and neurotrophins. Lesion of the cholinergic system in the basal forebrain was induced in rats by the immunotoxin 192IgG-saporin. Alzet osmotic minipumps for chronic release (over a period of 14 days) of mitogens [epidermal growth factor (EGF) or basic fibroblast growth factor (bFGF)] were implanted in animals with behavioral and biochemical cholinergic defect and connected to an intracerebroventricular catheter. After 14 days of delivery, these pumps were replaced by others delivering nerve growth factor (NGF) for an additional 14 days. At the same time, retinoic acid was added to the rats' food pellets for one month. Whereas the lesion decreased proliferative activity, EGF and bFGF both increased the numbe...Continue Reading

References

Feb 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J C HedreenD L Price
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L Aloe
Oct 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·V Bocchini, P U Angeletti
May 20, 1999·Journal of Neuropathology and Experimental Neurology·J Namiki, C H Tator
May 18, 2000·Nature Neuroscience·A Björklund, O Lindvall
Sep 23, 2000·Molecular and Cellular Endocrinology·M Páez PeredaG K Stalla
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·J FallonS Loughlin
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·K JinD A Greenberg
Aug 4, 2001·Stroke; a Journal of Cerebral Circulation·Y YagitaM Matsumoto
Dec 1, 2001·Biochemical and Biophysical Research Communications·I VuillaumeB Sablonnière
Dec 18, 2001·Journal of Neuroscience Research·S G KernieL F Parada
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Laura CalzaLuciana Giardino
Aug 6, 2002·Nature Medicine·Andreas ArvidssonOlle Lindvall
Sep 3, 2002·Nature Medicine·Evan Y Snyder, Kook I Park

❮ Previous
Next ❯

Citations

Sep 15, 2005·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Yong TangShu-Guang Yu
Jul 11, 2006·Neuro-Signals·Klaus HeeseNoriko Inoue
Dec 24, 2014·Journal of Cellular Physiology·Hany E S MareiCarlo Cenciarelli
Jun 10, 2014·Journal of Cellular Physiology·Hany E S MareiCarlo Cenciarelli
Jul 29, 2016·Neurogenesis·Brent AsricanChay T Kuo
Mar 13, 2012·Hormones and Behavior·Jesús DevesaVíctor Arce
Sep 21, 2007·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Antonio ChiarettiGiovanni Piedimonte
Jul 20, 2005·The European Journal of Neuroscience·Konrad LehmannGertraud Teuchert-Noodt
Jul 5, 2006·The European Journal of Neuroscience·Piercesare Grimaldi, Ferdinando Rossi
Sep 27, 2006·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Naoko KanekoKazunobu Sawamoto
Oct 24, 2012·Journal of Biomedical Materials Research. Part a·Zhaoyang YangXiaoguang Li
Feb 19, 2005·Neurobiology of Aging·Paul MohapelOlle Lindvall
Mar 28, 2006·Brain Research·Robert H Miller
Jul 23, 2014·Acta Neuropathologica Communications·Francesco GirolamoMaria Trojano
Jan 13, 2006·Neurobiology of Aging·Mia EmgårdLaura Calzà
Sep 6, 2005·Brain Research Bulletin·Karin Van der BorghtEddy A Van der Zee
Jun 25, 2017·Neuroscience and Biobehavioral Reviews·Angela IannitelliGiuseppe Bersani
Apr 6, 2018·Annual Review of Neuroscience·Ragnhildur T Káradóttir, Chay T Kuo
Jun 24, 2004·Journal of Neuroscience Research·Christiana M Cooper-KuhnH Georg Kuhn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.