Neural stem cells redefined: a FACS perspective

Molecular Neurobiology
Dragan Maric, Jeffery L Barker

Abstract

Using the generally accepted ontogenetic definition, neural stem cells (NSCs) are characterized as undifferentiated cells originating from the neuroectoderm that have the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors (LRP). LRPs can themselves undergo limited self-renewal, then ultimately differentiate into highly specialized cells that compose the nervous system. However, this physiologically delimited definition of NSCs has been increasingly blurred in the current state of the field, as the great majority of studies have retrospectively inferred the existence of NSCs based on their deferred functional capability rather than prospectively identifying the actual cells that created the outcome. Further complicating the matter is the use of a wide variety of neuroepithelial or neurosphere preparations as a source of putative NSCs, without due consideration that these preparations are themselves composed of heterogeneous populations of both NSCs and LRPs. This article focuses on recent attempts using FACS strategies to prospectively isolate NSCs from different types of LRPs as they appear in vivo and reveals the contrasting differences among these p...Continue Reading

Citations

Sep 29, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joseph A NielsenLynn D Hudson
Jan 20, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jonathan S GalTarik F Haydar
Jun 15, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Tao SunHua Xin
Nov 22, 2015·Neuroscience Letters·Kyriaki-Nefeli PoulatsidouNikolaos Grigoriadis
Mar 29, 2008·Molecular and Cellular Neurosciences·Luisa PintoMagdalena Götz
Aug 20, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ruben Adler
Oct 4, 2005·Neurological Research·Matthew N Meriggioli
May 5, 2011·Molecular and Cellular Endocrinology·Craig DorrellMarkus Grompe
Jan 15, 2005·Developmental Biology·Maria Beatriz C V GoncalvesJonathan P T Corcoran
Jan 31, 2017·Experimental Neurology·Raquel Martín-IbáñezJosep M Canals
Apr 23, 2008·Current Protocols in Neuroscience·Dragan Maric, Jeffery L Barker
May 2, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yasuhiro NakamuraMami Yamasaki
Sep 23, 2006·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Lawrence M Roth, Aleksander Talerman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved