Neural stem/progenitor cells participate in the regenerative response to perinatal hypoxia/ischemia.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Ryan J FellingS W Levison

Abstract

Perinatal hypoxia/ischemia (H/I) is the leading cause of neurologic injury resulting from birth complications. Recent advances in critical care have dramatically improved the survival rate of infants suffering this insult, but approximately 50% of survivors will develop neurologic sequelae such as cerebral palsy, epilepsy or cognitive deficits. Here we demonstrate that tripotential neural stem/progenitor cells (NSPs) participate in the regenerative response to perinatal H/I as their numbers increase 100% by 3 d and that they alter their intrinsic properties to divide using expansive symmetrical cell divisions. We further show that production of new striatal neurons follows the expansion of NSPs. Increased proliferation within the NSP niche occurs at 2 d after perinatal H/I, and the proliferating cells express nestin. Of those stem-cell related genes that change, the membrane receptors Notch1, gp-130, and the epidermal growth factor receptor, as well as the downstream transcription factor Hes5, which stimulate NSP proliferation and regulate stem cellness are induced before NSP expansion. The mechanisms for the reactive expansion of the NSPs reported here reveal potential therapeutic targets that could be exploited to amplify thi...Continue Reading

Associated Clinical Trials

Sep 4, 2014·Consuelo Mancias Guerra

Citations

Sep 9, 2011·Pediatric Radiology·L C TzarouchiMaria I Argyropoulou
Aug 19, 2007·Cell and Tissue Research·Yongsoo Kim, Francis G Szele
Nov 28, 2007·Cell and Tissue Research·Tomoaki Ikeda
May 8, 2008·Current Neurology and Neuroscience Reports·Joseph Scafidi, Vittorio Gallo
Sep 12, 2012·Bone Marrow Transplantation·Y LiaoM S Cairo
Feb 22, 2007·Nature Reviews. Neuroscience·Sylvian BauerPaul H Patterson
Mar 21, 2012·Pediatric Research·Cindy T J van VelthovenCobi J Heijnen
Nov 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yngve SejerstedMagnar Bjørås
Nov 18, 2009·Stem Cells and Development·Pedro M Pimentel-Coelho, Rosalia Mendez-Otero
Jun 1, 2012·Tissue Engineering. Part a·Yee-Shuan Lee, Treena Livingston Arinzeh
Aug 13, 2009·Developmental Neuroscience·Zinaida S Vexler, Midori A Yenari
Oct 7, 2010·Pediatric Research·Robin L HaynesHannah C Kinney
Jun 24, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Baoyuan BiFlora M Vaccarino
Jan 24, 2014·BioMed Research International·Ravi Kant Upadhyay
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Joshua J BreunigPasko Rakic
Sep 30, 2014·Experimental Neurology·Ryan J Felling, Hongjun Song
Jun 2, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Joey ScafidiFlora M Vaccarino
May 12, 2009·Journal of Neuroscience Methods·Kaisorn L ChaichanaAlfredo Quiñones-Hinojosa
Sep 17, 2015·Experimental Neurology·Jaylyn WaddellMargaret M McCarthy
Dec 4, 2008·Advances in Pediatrics·Michael K Fritsch, Don B Singer
Dec 15, 2007·Free Radical Biology & Medicine·Heung M LeeElla W Englander
Jan 25, 2007·Neurosurgery Clinics of North America·Elena I Fomchenko, Eric C Holland
Mar 1, 2007·Seminars in Fetal & Neonatal Medicine·Carina Mallard, Henrik Hagberg
Aug 27, 2015·Scientific Reports·Hainan LangJeremy L Barth
Dec 17, 2008·Biotechnology Journal·Carsten W Lederer, Niovi Santama
Feb 9, 2007·Annals of Neurology·Zhengang YangSteven W Levison
Jul 18, 2014·Neuron·Vittorio Gallo, Benjamin Deneen
Aug 23, 2008·The Journal of Comparative Neurology·Zhengang YangSteven W Levison
Aug 23, 2007·Journal of Neurochemistry·Michael J RomankoSteven W Levison

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