Neural substrates of reliability-weighted visual-tactile multisensory integration.

Frontiers in Systems Neuroscience
Michael S BeauchampTony Ro

Abstract

As sensory systems deteriorate in aging or disease, the brain must relearn the appropriate weights to assign each modality during multisensory integration. Using blood-oxygen level dependent functional magnetic resonance imaging of human subjects, we tested a model for the neural mechanisms of sensory weighting, termed "weighted connections." This model holds that the connection weights between early and late areas vary depending on the reliability of the modality, independent of the level of early sensory cortex activity. When subjects detected viewed and felt touches to the hand, a network of brain areas was active, including visual areas in lateral occipital cortex, somatosensory areas in inferior parietal lobe, and multisensory areas in the intraparietal sulcus (IPS). In agreement with the weighted connection model, the connection weight measured with structural equation modeling between somatosensory cortex and IPS increased for somatosensory-reliable stimuli, and the connection weight between visual cortex and IPS increased for visual-reliable stimuli. This double dissociation of connection strengths was similar to the pattern of behavioral responses during incongruent multisensory stimulation, suggesting that weighted co...Continue Reading

Citations

Feb 28, 2016·Neuropsychologia·Juliane Krueger FisterMark T Wallace
Feb 25, 2015·Human Brain Mapping·Jakub Limanowski, Felix Blankenburg
Jul 11, 2013·Neural Plasticity·Wen Qin, Chunshui Yu
Jul 31, 2012·Current Biology : CB·Iris VilaresKonrad P Kording
Dec 17, 2014·Neuropsychologia·Manasa KandulaH Chris Dijkerman
Sep 25, 2017·The European Journal of Neuroscience·Stephanie C BoyleChristoph Kayser
Oct 26, 2012·Proceedings. Biological Sciences·Benjamin de HaasGeraint Rees
Feb 22, 2018·Journal of Neurophysiology·Yang LiuHannah J Block
Jul 19, 2021·Cerebral Cortex·James K MoranDaniel Senkowski

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