Neural systems for word meaning modulated by semantic ambiguity

NeuroImage
Alice H D ChanLi Hai Tan

Abstract

One important issue in neuroimaging research on language is how the brain processes and represents lexical semantics. Past studies with various paradigms reveal that the left inferior prefrontal and mid-superior temporal regions play a crucial role in semantic processing. Those studies, however, typically utilize words having a precise and dominant meaning as stimuli and have not manipulated lexico-semantic ambiguity, a key feature of human language, as an experimental variable. Here, we used a word generation paradigm to examine whether neuroanatomical networks for meaning are modulated by lexical ambiguity. We found that, compared with semantically precise words, semantically ambiguous words were mediated by strong brain activations in the left dorsal-lateral frontal areas, the anterior cingulate, and the right inferior parietal lobe. Semantically precise words, instead, were associated with the left inferior prefrontal and mid-superior temporal sites. These findings indicate that semantic analysis of written words is a dynamic process involving coordination of widely distributed neural subsystems, which are weighted by semantic ambiguity.

References

Jan 1, 1985·Journal of Computer Assisted Tomography·P T FoxM E Raichle
Nov 16, 1995·Nature·M D'EspositoM Grossman
Feb 1, 1994·Trends in Neurosciences·M I Posner, S Dehaene
Mar 1, 1993·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·P J Snyder, L J Harris
Jul 11, 1996·Nature·P T FoxJ L Lancaster
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·S L Thompson-SchillM J Farah
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·J D GabrieliJ E Desmond
Dec 1, 1998·Journal of Cognitive Neuroscience·C J MummeryC J Price
Mar 12, 1999·Science·E E Smith, J Jonides
Apr 13, 1999·Lancet·R J WiseS K Scott
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·M LepageE Tulving
Feb 24, 2001·Neuroreport·L H TanJ H Gao
Apr 13, 2001·Current Opinion in Neurobiology·A Martin, L L Chao
May 4, 2001·Brain : a Journal of Neurology·P C Fletcher, R N Henson
Sep 21, 2001·Journal of Cognitive Neuroscience·A L RoskiesS E Petersen
Nov 1, 1997·Journal of Cognitive Neuroscience·C J PriceR J Wise
Apr 1, 1989·Journal of Cognitive Neuroscience·S E PetersenM E Raichle

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Citations

Sep 25, 2007·Brain Research·Emily R SternJennifer A Mangels
Apr 19, 2008·Journal of the International Neuropsychological Society : JINS·Helen J CheneryDavid A Copland
Aug 16, 2008·Journal of Cognitive Neuroscience·Natalia Y BilenkoSheila E Blumstein
Mar 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Chris M BirdAnna Franklin
Dec 18, 2012·Psychopharmacology·Tristan J WatkinsRonald L Cowan
Jul 15, 2006·Journal of Cognitive Neuroscience·Emily R Stern, Jennifer A Mangels
Feb 5, 2013·Brain and Language·Fan-pei Gloria YangDaniel C Krawczyk
Dec 19, 2006·Brain Research·David A CoplandMatt Eastburn
Apr 17, 2007·Brain Research·Robert A Mason, Marcel Adam Just
Nov 9, 2005·NeuroImage·Tai-Li ChouNadia E Cone
Feb 7, 2015·Brain and Language·Aya Meltzer-AsscherCynthia K Thompson
Jan 27, 2009·NeuroImage·Klaus Hoenig, Lukas Scheef
Jul 6, 2007·NeuroImage·Mante S NieuwlandJos J A Van Berkum
Dec 5, 2006·NeuroImage·Monika-Zita ZempleniLaurie A Stowe
Feb 27, 2007·NeuroImage·Silvia P GennariMark S Seidenberg
Dec 3, 2014·Brain and Language·Christopher M GrindrodDirk B den Ouden
Jan 1, 2013·Language and Cognitive Processes·Aya Meltzer-AsscherCynthia K Thompson
Aug 12, 2017·Frontiers in Human Neuroscience·Veronica P Y KwokLi-Hai Tan
Nov 30, 2016·Brain and Language·Elizabeth Musz, Sharon L Thompson-Schill

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