Abstract
1. The central structures responsible for the gastrosecretory effect of cytoglucopoenia caused by 2-deoxy-D-glucose (2-DG) were investigated in 105 cats prepared with chronic gastric fistulae and subjected to various experimental procedures. 2. Bilateral electrolytic lesion of the caudalmost two thirds of globus pallidus almost suppressed the secretory response and caused aphagia and adipsia. 3. Secretion in response to 2-DG and feeding behaviour were entirely blocked after making a lesion in a large ventromedial area of the meso diencephalic transition comprising the ventral tegmental area of Tsai, the ventral tegmental decussation, the red nucleus, a ventral portion of the central grey matter, the interstitial nuclei of Darkschewitsch and of Cajal, the pre-rubral fields, the reticular part of substantia nigra, the internal portion of the cerebral peduncle and the ventral part of the mesencephalic reticular formation. 4. Microinjection of 2-DG in the medial forebrain bundle, at the level of the hypothalamus, caused intense gastric secretion, whereas the same procedure was totally ineffective when the caudalmost two thirds of the globus pallidus were stimulated. 5. Increasing doses of 2-DG, systemically injected, restored the s...Continue Reading
Citations
Jan 1, 1990·Neuropharmacology·M MuramatsuH Aihara
Jan 1, 1984·Digestive Diseases and Sciences·H SarlesD Schmidt
Sep 1, 1984·Journal of the Autonomic Nervous System·M W GunionF X Pi-Sunyer
Feb 14, 1995·Regulatory Peptides·T OkumuraT N Pappas
Jan 1, 1985·Physiology & Behavior·N S Hell, C Timo-Iaria
May 1, 1980·Brain Research Bulletin·T Shiraishi
Mar 1, 1980·Brain Research Bulletin·A Simpson, T Shiraishi
Dec 1, 1978·Physiology & Behavior·H J Silverman
Feb 10, 2006·Domestic Animal Endocrinology·Takanori IdaKenji Kangawa
Oct 13, 2009·Molecular Biology Reports·Qinggang XuMuyuan Zhu
Nov 5, 2019·Neuroscience Letters·Toshikatsu OkumuraMasumi Ohhira
May 23, 2020·Neuropharmacology·Masatomo IshiohToshikatsu Okumura
Mar 28, 2021·Experimental Neurology·Masatomo IshiohToshikatsu Okumura
Mar 13, 1995·Brain Research·T OkumuraT N Pappas
Aug 1, 1979·Physiology & Behavior·M S DolnikoffC Timo-Iaria
Oct 10, 2020·Biochemical Pharmacology·Sho IgarashiToshikatsu Okumura