PMID: 1206568Nov 1, 1975Paper

Neural systems responsible for the gastric secretion provoked by 2-deoxy-D-glucose cytoglucopoenia

The Journal of Physiology
M KadekaroL E Valle

Abstract

1. The central structures responsible for the gastrosecretory effect of cytoglucopoenia caused by 2-deoxy-D-glucose (2-DG) were investigated in 105 cats prepared with chronic gastric fistulae and subjected to various experimental procedures. 2. Bilateral electrolytic lesion of the caudalmost two thirds of globus pallidus almost suppressed the secretory response and caused aphagia and adipsia. 3. Secretion in response to 2-DG and feeding behaviour were entirely blocked after making a lesion in a large ventromedial area of the meso diencephalic transition comprising the ventral tegmental area of Tsai, the ventral tegmental decussation, the red nucleus, a ventral portion of the central grey matter, the interstitial nuclei of Darkschewitsch and of Cajal, the pre-rubral fields, the reticular part of substantia nigra, the internal portion of the cerebral peduncle and the ventral part of the mesencephalic reticular formation. 4. Microinjection of 2-DG in the medial forebrain bundle, at the level of the hypothalamus, caused intense gastric secretion, whereas the same procedure was totally ineffective when the caudalmost two thirds of the globus pallidus were stimulated. 5. Increasing doses of 2-DG, systemically injected, restored the s...Continue Reading

Citations

Sep 1, 1984·Journal of the Autonomic Nervous System·M W GunionF X Pi-Sunyer
Jan 1, 1985·Physiology & Behavior·N S Hell, C Timo-Iaria
Mar 1, 1980·Brain Research Bulletin·A Simpson, T Shiraishi
Dec 1, 1978·Physiology & Behavior·H J Silverman
Feb 10, 2006·Domestic Animal Endocrinology·Takanori IdaKenji Kangawa
Oct 13, 2009·Molecular Biology Reports·Qinggang XuMuyuan Zhu
Nov 5, 2019·Neuroscience Letters·Toshikatsu OkumuraMasumi Ohhira

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