PMID: 8610522Jan 1, 1995Paper

Neural tolerability of iodixanol in mice and dogs after single and repeated intracisternal administration

Acta Radiologica. Supplementum
L E LarsenW F Blazak

Abstract

The neural tolerability of iodixanol has been assessed in studies in mice and dogs. The animals received up to 4 injections in the cisterna cerebellomedullaris while under light anesthesia. Iotrolan was included as a reference study in 1 study. The observations comprised assessment of clinical behavior, cerebrospinal fluid analysis, hematology, clinical chemistry and/or macroscopic and microscopic examination at necropsy. In addition, the repeated-dose dog study, urinalysis and opthalmoscopy were performed, electrocardiograms obtained, and respiratory rate, blood pressure and rectal temperature measured. Clinical signs and minor pathological changes caused by the injection procedures were seen in all studies in some animals treated with iodixanol as well as in control animals. Single (2.0 g I/kg) and repeated (0.960 g I/kg) intracisternal administration of iodixanol to mice caused no significant toxicological effects. Two dogs treated with a high dose of iodixanol (0.256 g I/kg; 0.8 ml/kg) had pathological changes (meningeal inflammation and/or necrosis) that were more severe than those observed in control dogs. Single and repeated intracisternal administration of 0.128 g I/kg (0.4 ml/kg) of iodixanol to dogs, however, caused n...Continue Reading

References

Jan 1, 1985·Investigative Radiology·J T Lamb
Sep 1, 1985·The British Journal of Radiology·P MacphersonA McGeorge
Jan 1, 1983·Acta Radiologica: Diagnosis·B KendallA Schneidau
Jul 2, 1959·Annals of the New York Academy of Sciences·J O HOPPE

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Citations

Jan 1, 1996·European Radiology·J O Karlsson
Sep 26, 2020·Biotechnology Journal·Jihad El Andari, Dirk Grimm

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