PMID: 8949699Sep 1, 1996Paper

Neural tube defects 1974-94--down but not out

Archives of Disease in Childhood. Fetal and Neonatal Edition
M MurphyB Botting

Abstract

To describe accurately the total prevalence of neural tube defects (NTDs) in England and Wales over time, and to provide a benchmark up to 1994. National data about NTDs reported as births or terminations are available from 1974-94, but reporting is incomplete. A local register of NTDs covering Oxfordshire/west Berkshire from 1965-94 was used to validate national data for the locality, using the method of capture and recapture, and hence to estimate incompleteness of reporting nationally. National underreporting is consistent at about two thirds of the true number of cases reaching at least the second trimester. The local register is much more complete, but time trends locally and nationally are similar. In England and Wales total prevalence declined from about 34 per 10000 live and stillbirths in 1974 to a plateau of just under 8 per 10000 in the 1990s. The decline in NTD prevalence is real and seems to have stopped. How this relates to changes in diet or the practice of vitamin supplementation is unknown, and the implications of the plateau are uncertain. OPCS figures of 500 NTDs annually in England and Wales represent about two thirds of the true number of cases.

References

Nov 1, 1994·Archives of Disease in Childhood. Fetal and Neonatal Edition·K HeyB Botting
Jan 1, 1994·BMJ : British Medical Journal·R E Laporte

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Citations

Feb 19, 1999·BMJ : British Medical Journal·N O JeelaniJ A Punt
Jul 10, 1999·BMJ : British Medical Journal·E Alberman, J M Noble
Aug 19, 2000·BMJ : British Medical Journal·S Richmond, B Brown
Mar 7, 2015·Journal of Public Health·Joan K MorrisAnna L Springett
Oct 8, 1998·British Journal of Obstetrics and Gynaecology·F MathewsA Neil
May 13, 2014·Clinical Medicine Insights. Women's Health·Mark Maher, Remon Keriakos
Jul 20, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·M MurphyJ Wild
Jun 20, 2017·Annual Review of Nutrition·Anne M MolloyLawrence C Brody
Sep 13, 2005·The Spine Journal : Official Journal of the North American Spine Society·Kevin M KaplanJohn A Bendo

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