Neurally adjusted ventilatory assist improves patient–ventilator interaction in infants as compared with conventional ventilation

Pediatric Research
Alice BordessouleJennifer Beck

Abstract

Neurally adjusted ventilatory assist (NAVA) is a mode of ventilation controlled by the electrical activity of the diaphragm (Edi). The aim was to evaluate patient-ventilator interaction in infants during NAVA as compared with conventional ventilation. Infants were successively ventilated with NAVA, pressure control ventilation (PCV), and pressure support ventilation (PSV). Edi and ventilator pressure (Pvent) waveforms were compared and their variability was assessed by coefficients of variation. Ten patients (mean age 4.3 ± 2.4 mo and weight 5.9 ± 2.2 kg) were studied. In PCV and PSV, 4 ± 4.6% and 6.5 ± 7.7% of the neural efforts failed to trigger the ventilator. This did not occur during NAVA. Trigger delays were shorter with NAVA as compared with PCV and PSV (93 ± 20 ms vs. 193 ± 87 ms and 135 ± 29 ms). During PCV and PSV, the ventilator cycled off before the end of neural inspiration in 12 ± 13% and 21 ± 19% of the breaths (0 ± 0% during NAVA). During PCV and PSV, 24 ± 11% and 25 ± 9% of the neural breath cycle was asynchronous with the ventilator as compared with 11 ± 3% with NAVA. A large variability was observed for Edi in all modes, which was transmitted into Pvent during NAVA (coefficient of variation: 24 ± 8%) and not ...Continue Reading

References

Jul 1, 1988·Journal of Applied Physiology·M J TobinM A Sackner
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·M J TobinR F Lodato
Feb 26, 1998·American Journal of Respiratory and Critical Care Medicine·J P VialeG Annat
May 29, 1998·Nature·B SukiH E Stanley
Dec 2, 1999·Nature Medicine·C SinderbyL Lindström
Sep 1, 2000·Respiration Physiology·G Benchetrit
Aug 23, 2001·Respiratory Care Clinics of North America·H L DuY Yamada
May 7, 2002·American Journal of Respiratory and Critical Care Medicine·Thomas BrackMartin J Tobin
Aug 21, 2002·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society/European Respiratory Society
Jan 24, 2004·Pediatric Research·Jennifer BeckChrister Sinderby
Aug 10, 2006·Intensive Care Medicine·Arnaud W ThilleLaurent Brochard
Dec 19, 2006·Journal of Critical Care·Peter J PronovostLaura L Morlock
Feb 24, 2009·Archivos de bronconeumología·Joaquim GeaAlejandro Grassino
Mar 11, 2009·Journal of Critical Care·Marjolein de WitScott K Epstein
Jul 14, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jan A Bengtsson, Karl Erik Edberg
Jul 14, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Cormac BreatnachBrendan P O'Hare
May 11, 2010·Neonatology·Guillaume EmeriaudGila Benchetrit
Sep 28, 2010·Intensive Care Medicine·Lise PiquilloudDidier Tassaux
Mar 23, 2011·Intensive Care Medicine·Hadrien RozéAlexandre Ouattara
Jun 16, 2011·Intensive Care Medicine·Mohamed Y Rady, Joseph L Verheijde
Aug 11, 2011·Pediatric Pulmonology·Merja AlanderTero Kontiokari
Dec 6, 2011·The Journal of Pediatrics·Howard Stein, Diane Howard

❮ Previous
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Citations

Jul 12, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Laurence VignauxPeter C Rimensberger
Jul 19, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Laurence VignauxPeter C Rimensberger
Oct 29, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jose Ramet, Jozef De Dooy
Nov 19, 2013·Seminars in Fetal & Neonatal Medicine·Howard Stein, Kimberly Firestone
Oct 18, 2013·Critical Care : the Official Journal of the Critical Care Forum·Christer SinderbyJennifer Beck
Mar 20, 2013·Critical Care Research and Practice·Laurence Ducharme-CrevierGuillaume Emeriaud
Aug 15, 2014·Intensive Care Medicine·Guillaume EmeriaudPhilippe Jouvet
May 6, 2015·Pediatric Pulmonology·Alexandrine LaroucheGuillaume Emeriaud
Apr 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·Laurence Ducharme-CrevierGuillaume Emeriaud
Mar 10, 2015·Frontiers in Pediatrics·Hau-Tieng WuGuillaume Emeriaud
Dec 17, 2014·Frontiers in Pediatrics·Florent BaudinGuillaume Emeriaud
Dec 1, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Pradeep V MallySean M Bailey
Dec 22, 2017·Annals of Intensive Care·Guillaume MortametGuillaume Emeriaud
Oct 28, 2017·The Cochrane Database of Systematic Reviews·Thomas E RossorAnne Greenough
Nov 26, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ana C YaguiCelso M Rebello
Jul 17, 2019·Annals of the American Thoracic Society·Marie-Pier VeilletGuillaume Emeriaud
Feb 26, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Robert G T BlokpoelMartin C J Kneyber
Feb 23, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Guillaume MortametGuillaume Emeriaud
May 21, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Sandrine EssouriGuillaume Emeriaud
Dec 6, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Young Hwa JungJung-Hwan Choi
Apr 8, 2018·BMC Pulmonary Medicine·Giorgio ContiRoberta Costa
Apr 18, 2017·F1000Research·Nicolas NardiPhilippe Jouvet
Jun 3, 2015·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Peter C RimensbergerUNKNOWN Pediatric Acute Lung Injury Consensus Conference Group
Feb 10, 2017·European Journal of Pediatrics·Sandeep ShettyAnne Greenough
Apr 15, 2021·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Julia HarrisJos M Latour
Jun 1, 2021·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Robert G T BlokpoelMartin C J Kneyber

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