Neuraminidase-Inhibiting Antibody Response to H5N1 Virus Vaccination in Chronically Ill and Immunocompromised Patients

Open Forum Infectious Diseases
Richard FritzThomas R Kreil

Abstract

Neuraminidase-inhibiting (NAi) antibodies have been reported to be an independent correlate of protection from influenza disease, but the NAi antibody response to influenza vaccination has never been assessed in chronically ill or immunocompromised participants. Using an enzyme-linked lectin assay, we demonstrated that 2 immunizations with a Vero cell culture-derived, whole-virus H5N1 A/Vietnam vaccine induces NAi antibodies in 94.3% of chronically ill and 83.8% of immunocompromised participants. A booster with a heterologous A/Indonesia H5N1 vaccine induced comparable NAi antibody titers in both groups and resulted in 100% seropositivity. These data support prepandemic H5N1 vaccination strategies for these highly vulnerable risk groups.

References

Feb 1, 1968·Journal of Virology·E D KilbourneR G Webster
Jun 22, 1972·The New England Journal of Medicine·B R MurphyR M Chanock
Oct 28, 2004·Journal of Virology·Mikhail N MatrosovichHans-Dieter Klenk
Jun 14, 2008·The New England Journal of Medicine·Hartmut J EhrlichUNKNOWN Baxter H5N1 Pandemic Influenza Vaccine Clinical Study Team
Oct 1, 2009·Emerging Infectious Diseases·Sathit PichyangkulMark M Fukuda
Nov 18, 2011·The Journal of Infectious Diseases·Richard FritzThomas R Kreil
Jun 23, 2012·Nature·David M MorensJeffery K Taubenberger
Sep 18, 2013·The Journal of Infectious Diseases·Maikel V W van der VeldenGerald Aichinger
Apr 18, 2014·Clinical and Vaccine Immunology : CVI·Maikel V W van der VeldenGerald Aichinger

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Datasets Mentioned

BETA
EF541467.1

Clinical Trials Mentioned

NCT00711295

Software Mentioned

Minitab

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