Neuraminidase promotes neutrophil, lymphocyte and macrophage infiltration in the normal rat kidney

Kidney International
C MarínB Rodríguez-Iturbe

Abstract

Neuraminidase (NA) is an enzyme produced by several microorganisms, which is capable of liberating sialic acid from glycoproteins and modifying cellular adhesion mechanisms. NA is considered a virulence factor in some bacterial species and has been implicated in the pathogenesis of acute poststreptococcal glomerulonephritis, a disease in which glomerular leukocyte infiltration is a prominent feature. We examined the effect of NA on kidney infiltration by neutrophils (PMN), T lymphocytes (TL) and monocyte-macrophages (MM). Intravenous injection of NA resulted in an early increase in the number of PMN (1 hr, 3.42 +/- 0.19 cells/cgs, mean +/- SEM; 3 hr, 3.63 +/- 0.13; 6 hr, 2.9 +/- 0.24; controls, 1.53 +/- 0.18; P < 0.001) and MM (1 hr, 3.49 +/- 0.16; 3 hr, 4.02 +/- 0.2; 6 hr, 3.88 +/- 0.27; controls 1.43 +/- 0.14; P < 0.001) in the glomeruli, while TL increased later (24 hr, 2.29 +/- 0.14; 48 hr, 2.4 +/- 0.2; 72 hr, 2.16 +/- 0.15; controls 0.7 +/- 0.07; P < 0.001). PMN and TL were also increased in the interstitium (up to ninefold for PMN and up to threefold for TL). Following i.v. injection of 51Cr-labeled NA-treated leukocytes, renal radioactive uptake was significantly increased at all times tested (percent radioactivity/gram ...Continue Reading

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Citations

Apr 11, 2006·Zoological Science·Toshio OkazakiTatsuo Nagai
Mar 8, 2007·Kidney International·B Rodríguez-Iturbe, S Batsford
Oct 9, 2020·International Reviews of Immunology·Jesús Mosquera, Adriana Pedreañez
Sep 7, 2000·The Veterinary Record·B P Sturgeon, H Bassett
Feb 4, 2021·Journal of the American Society of Nephrology : JASN·Bernardo Rodriguez-Iturbe

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