Neuregulin-1 elicits a regulatory immune response following traumatic spinal cord injury

Journal of Neuroinflammation
Arsalan AlizadehSoheila Karimi-Abdolrezaee

Abstract

Spinal cord injury (SCI) triggers a robust neuroinflammatory response that governs secondary injury mechanisms with both degenerative and pro-regenerative effects. Identifying new immunomodulatory therapies to promote the supportive aspect of immune response is critically needed for the treatment of SCI. We previously demonstrated that SCI results in acute and permanent depletion of the neuronally derived Neuregulin-1 (Nrg-1) in the spinal cord. Increasing the dysregulated level of Nrg-1 through acute intrathecal Nrg-1 treatment enhanced endogenous cell replacement and promoted white matter preservation and functional recovery in rat SCI. Moreover, we identified a neuroprotective role for Nrg-1 in moderating the activity of resident astrocytes and microglia following injury. To date, the impact of Nrg-1 on immune response in SCI has not yet been investigated. In this study, we elucidated the effect of systemic Nrg-1 therapy on the recruitment and function of macrophages, T cells, and B cells, three major leukocyte populations involved in neuroinflammatory processes following SCI. We utilized a clinically relevant model of moderately severe compressive SCI in female Sprague-Dawley rats. Nrg-1 (2 μg/day) or saline was delivered s...Continue Reading

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Citations

Feb 23, 2019·Developmental Neurobiology·Polina D FreitasJames R Monaghan
May 2, 2019·Journal of Neuroinflammation·Daniel J HellenbrandAmgad S Hanna
Jul 17, 2020·The International Journal of Neuroscience·Igor Jakovcevski, Melitta Schachner
May 16, 2019·Stem Cells International·Ghazaleh M ShahriarySoheila Karimi-Abdolrezaee
Jul 22, 2020·Alzheimer's Research & Therapy·François Mouton-LigerClaire Paquet
Jan 23, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Guillem Mòdol-CaballeroMireia Herrando-Grabulosa
Feb 13, 2021·Brain : a Journal of Neurology·Trevor J Kilpatrick, Michele D Binder
Dec 15, 2020·Brain : a Journal of Neurology·Hardeep KatariaSoheila Karimi-Abdolrezaee
Mar 6, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Narjes ShahsavaniSoheila Karimi-Abdolrezaee

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Methods Mentioned

BETA
flow cytometry
chemokine

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