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Neuregulin 1 regulates amyloid precursor protein cell surface expression and non-amyloidogenic processing

Journal of Pharmacological Sciences

Jun 20, 2018

Young-Jung KimRan-Sook Woo

Abstract

The amyloid precursor protein (APP) is a key molecule in Alzheimer's disease. The prevailing view is that APP is initially transported to the plasma membrane as a full-length protein. Its localization at the cell surface can trigger downstream signaling and APP cleavage. Our previous wo...read more

Mentioned in this Paper

Establishment and Maintenance of Localization
Study
Nrg1 protein, rat
Adam10
NRG1 protein, human
Neurons
Amyloid Beta Precursor Protein Measurement
Cell Culture Techniques
Cytokinesis of the Fertilized Ovum
ADAM10
1
6
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Neuregulin 1 regulates amyloid precursor protein cell surface expression and non-amyloidogenic processing

Journal of Pharmacological Sciences

Jun 20, 2018

Young-Jung KimRan-Sook Woo

PMID: 29914798

DOI: 10.1016/j.jphs.2018.05.004

Abstract

The amyloid precursor protein (APP) is a key molecule in Alzheimer's disease. The prevailing view is that APP is initially transported to the plasma membrane as a full-length protein. Its localization at the cell surface can trigger downstream signaling and APP cleavage. Our previous wo...read more

Mentioned in this Paper

Establishment and Maintenance of Localization
Study
Nrg1 protein, rat
Adam10
NRG1 protein, human
Neurons
Amyloid Beta Precursor Protein Measurement
Cell Culture Techniques
Cytokinesis of the Fertilized Ovum
ADAM10
1
6

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Limbic System

The limbic system is comprised of several different parts of the brain involved in emotion, motivation, learning, and memory. Discover the latest research on the limbic system here.

Alzheimer's Disease: Transcription

Transcription involves copying (transcribing) the gene's DNA sequence into RNA. Impaired transcription is associated with the pathogenesis and progression of conditions such as Alzheimer's disease (AD). Here are the latest discoveries pertaining to transcription and this disease.

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