Neuregulin-1 signaling in brain endothelial cells.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Josephine LokEng H Lo

Abstract

Neuregulin-1 (NRG1) signaling has multiple functions in neurons and glia. The data in this study show that NRG1 may also possess significant signaling and cytoprotective properties in human brain microvascular endothelial cells (BMECs). Neuregulin-1 mRNA and protein expression are present in these cells, and NRG1 receptors erbB2 and erbB3 are phosphorylated in response to NRG1. Neuregulin-1 triggers clear biologic responses in BMECs--elevated phospho-Akt levels, increased ring formation in a Matrigel assay, and decreased cell death after oxidative injury with H(2)O(2). These data suggest that NRG1 signaling is functional and cytoprotective in BMECs.

References

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Citations

Jul 10, 2012·Translational Stroke Research·Josephine LokEng H Lo
Jan 18, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Radwan N SafaDouglas B Sawyer
Oct 30, 2012·Circulation Research·Oghenerukevwe OdieteDouglas B Sawyer
Nov 16, 2013·Current Heart Failure Reports·Cristi L GalindoDouglas B Sawyer
Aug 3, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Norifumi TanakaYoshiki Kudo
Sep 8, 2009·Brain, Behavior, and Immunity·Insa HoffmannChristiane E L Dammann
Nov 20, 2012·Electrophoresis·Mingming NingEng H Lo
Jan 19, 2017·International Journal of Molecular Sciences·Jodi M SaunusSunil R Lakhani
Jul 29, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maj S ThomsenTorben Moos
Oct 24, 2018·Journal of Perinatal Medicine·Sebastian Rupert HobsonDan Farine
Oct 15, 2019·Circulation. Heart Failure·Gilles W De KeulenaerVincent F M Segers
Aug 21, 2020·Learning & Memory·Jack T Rogers, Catherine M Cahill

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Methods Mentioned

BETA
X-ray
immunoprecipitation
Assay

Software Mentioned

SAS

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