Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium

Circulation Research
Donna LaiRichard P Harvey

Abstract

The cardiac gene regulatory network (GRN) is controlled by transcription factors and signaling inputs, but network logic in development and it unraveling in disease is poorly understood. In development, the membrane-tethered signaling ligand Neuregulin (Nrg)1, expressed in endocardium, is essential for ventricular morphogenesis. In adults, Nrg1 protects against heart failure and can induce cardiomyocytes to divide. To understand the role of Nrg1 in heart development through analysis of null and hypomorphic Nrg1 mutant mice. Chamber domains were correctly specified in Nrg1 mutants, although chamber-restricted genes Hand1 and Cited1 failed to be activated. The chamber GRN subsequently decayed with individual genes exhibiting decay patterns unrelated to known patterning boundaries. Both trabecular and nontrabecular myocardium were affected. Network demise was spatiotemporally dynamic, the most sensitive region being the central part of the left ventricle, in which the GRN underwent complete collapse. Other regions were partially affected with graded sensitivity. In vitro, Nrg1 promoted phospho-Erk1/2-dependent transcription factor expression, cardiomyocyte maturation and cell cycle inhibition. We monitored cardiac pErk1/2 in embry...Continue Reading

References

Nov 23, 1995·Nature·D Meyer, C Birchmeier
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·R G GourdieT Mikawa
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·X LiuM Zhou
Jul 7, 2000·Developmental Biology·V M ChristoffelsA F Moorman
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Stacey RentschlerGlenn I Fishman
Sep 6, 2002·Biochemical Pharmacology·Jacques PouysségurPhilippe Lenormand
May 31, 2003·Circulation Research·Maria ReckovaDavid Sedmera
Sep 25, 2003·Physiological Reviews·Antoon F M Moorman, Vincent M Christoffels
Feb 10, 2004·Molecular Biology of the Cell·Christina R Kahl, Anthony R Means
Sep 2, 2004·Molecular and Cellular Biology·Joanne M BrittoSamantha J Busfield
Jan 28, 2005·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Angela Clerk, Peter H Sugden
Mar 11, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Rita Patel, Lidia Kos
Aug 3, 2005·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·David SedmeraRobert P Thompson
Nov 24, 2005·Nature Reviews. Genetics·Margaret BuckinghamStéphane Zaffran
May 30, 2006·Developmental Biology·José Rivera-Feliciano, Clifford J Tabin
Aug 5, 2006·Circulation Research·Alexandre T SoufanAntoon F M Moorman
Feb 10, 2007·Seminars in Cell & Developmental Biology·Takashi Mikawa, Romulo Hurtado
Mar 6, 2007·Developmental Cell·Joaquín Grego-BessaJosé Luis de la Pompa
Mar 24, 2007·Cellular and Molecular Life Sciences : CMLS·W M H HoogaarsV M Christoffels
Oct 26, 2007·The Journal of Investigative Dermatology·Olivia WansburyBeatrice Howard
Jan 26, 2008·Circulation Research·Heather J Evans-AndersonKatherine E Yutzey
May 15, 2008·Nature Reviews. Neuroscience·Lin Mei, Wen-Cheng Xiong
Sep 20, 2008·Experimental Cell Research·Laura Pentassuglia, Douglas B Sawyer
Aug 8, 2009·Circulation Research·Reena SinghAndreas Kispert
Aug 18, 2009·Lancet·David J BarronWilliam J Brawn

❮ Previous
Next ❯

Citations

Oct 12, 2010·Cardiovascular Research·Francesca Rochais, Rodolphe Fischmeister
Mar 4, 2011·Cardiovascular Research·David Sedmera
Mar 20, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Brian Wadugu, Bernhard Kühn
Jun 6, 2012·Biochemistry Research International·Alexander T Mikhailov, Mario Torrado
May 21, 2011·Circulation Research·Nathaniel L TullochCharles E Murry
Mar 31, 2012·Circulation Research·Ying Tian, Edward E Morrisey
Oct 30, 2012·Circulation Research·Oghenerukevwe OdieteDouglas B Sawyer
Oct 28, 2010·Development·Jiandong LiuDidier Y R Stainier
Sep 21, 2011·PloS One·Mauro W CostaRichard P Harvey
Jun 19, 2012·Differentiation; Research in Biological Diversity·Shu Tu, Neil C Chi
Jul 12, 2013·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Wenjun ZhangWeinian Shou
Jan 20, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Courtney PeshkovskyDeborah Yelon
Apr 4, 2015·Science Translational Medicine·Brian D PolizzottiBernhard Kühn
Oct 16, 2012·Developmental Biology·Cristina HarmelinkKai Jiao
May 10, 2017·Nature Communications·S Javad Rasouli, Didier Y R Stainier
Feb 4, 2016·Development·Milena B FurtadoNadia A Rosenthal
Jul 7, 2018·Circulation Research·Ronald J VagnozziSteven R Houser
Oct 9, 2019·Cardiovascular Research·Yidong WangBin Zhou
May 22, 2019·JCI Insight·Xianghu QuH Scott Baldwin
Jul 11, 2020·Current Cardiology Reports·Josef Finsterer, Claudia Stöllberger
Jul 1, 2016·Physiological Reviews·Jianchun ChenRaymond C Harris
Jan 10, 2017·The Journal of Clinical Investigation·Maretoshi HiraiSylvia M Evans
Dec 22, 2017·Journal of Cellular and Molecular Medicine·Daniel BrownJiandong Liu
Jun 8, 2018·Nature Reviews. Cardiology·Vincent W W van EifVincent M Christoffels
Oct 25, 2016·The Journal of Clinical Investigation·Akshay ShekharDavid S Park
Dec 2, 2020·International Journal of Molecular Sciences·Junjun LiYoshiki Sawa
Jan 28, 2021·Signal Transduction and Targeted Therapy·Rui GongBenzhi Cai
Feb 16, 2021·Frontiers in Cell and Developmental Biology·Yuwen ChenYing Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Developmental Cell
Joaquín Grego-BessaJosé Luis de la Pompa
Proceedings of the National Academy of Sciences of the United States of America
Stacey RentschlerGlenn I Fishman
Developmental Dynamics : an Official Publication of the American Association of Anatomists
Vincent M ChristoffelsMarina Campione
© 2021 Meta ULC. All rights reserved