Neuregulin directed molecular mechanisms of visual cortical plasticity

The Journal of Comparative Neurology
Steven F GriecoXiangmin Xu

Abstract

Experience-dependent critical period (CP) plasticity has been extensively studied in the visual cortex. Monocular deprivation during the CP affects ocular dominance, limits visual performance, and contributes to the pathological etiology of amblyopia. Neuregulin-1 (NRG1) signaling through its tyrosine kinase receptor ErbB4 is essential for the normal development of the nervous system and has been linked to neuropsychiatric disorders such as schizophrenia. We discovered recently that NRG1/ErbB4 signaling in PV neurons is critical for the initiation of CP visual cortical plasticity by controlling excitatory synaptic inputs onto PV neurons and thus PV-cell mediated cortical inhibition that occurs following visual deprivation. Building on this discovery, we review the existing literature of neuregulin signaling in developing and adult cortex and address the implication of NRG/ErbB4 signaling in visual cortical plasticity at the cellular and circuit levels. NRG-directed research may lead to therapeutic approaches to reactivate plasticity in the adult cortex.

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Citations

Oct 18, 2018·The Journal of Comparative Neurology·Afrida RahmanAnne L Prieto
Aug 28, 2019·The Journal of Comparative Neurology·Steven F GriecoXiangmin Xu
Aug 2, 2020·The Journal of Comparative Neurology·Takuji Kasamatsu, Kazuyuki Imamura
Feb 16, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Limin WuJosephine Lok
Jul 18, 2021·Journal of Biochemical and Molecular Toxicology·Limin XuLijuan Lang

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