PMID: 9159178May 27, 1997Paper

Neuregulins stimulate the functional expression of Ca2+-activated K+ channels in developing chicken parasympathetic neurons

Proceedings of the National Academy of Sciences of the United States of America
P Subramony, S E Dryer

Abstract

The developmental expression of macroscopic Ca2+-activated K+ currents (IK[Ca]) in chicken ciliary ganglion (CG) neurons is dependent in part on trophic factors released from preganglionic nerve terminals. Neuregulins are expressed in the preganglionic neurons that innervate the chicken CG and are therefore plausible candidates for this activity. Application of 1 nM beta1-neuregulin peptide for 12 hr evokes a large (7- to 10-fold) increase in IK[Ca] in embryonic day 9 CG neurons, even in the presence of a translational inhibitor. A similar posttranslational effect is produced by high concentrations (10 nM) of epidermal growth factor and type alpha transforming growth factor but not by 10 nM alpha2-neuregulin peptide or by neurotrophins at 40 ng.ml-1. beta1-neuregulin treatment for 12 hr also confers Ca2+ sensitivity onto large-conductance (285 pS) K+ channels observed in inside-out patches. beta-Neuregulins have no effect on voltage-activated Ca2+ currents of CG neurons. These data support the hypothesis that beta-neuregulins mediate the trophic effects of preganglionic nerve terminals on the electrophysiological differentiation of developing CG neurons.

References

Sep 1, 1992·Neuron·J Schlessinger, A Ullrich
May 22, 1992·Science·W E HolmesG D Lewis
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J C MartinouJ P Merlie
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D A HarrisG D Fischbach
Nov 23, 1995·Nature·D Meyer, C Birchmeier
Mar 1, 1994·Molecular and Cellular Biology·D WenV L Jacobsen
Jan 1, 1995·Neuron·G CorfasG D Fischbach
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G CorfasG D Fischbach
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·T K MorrisseyR P Bunge
Dec 2, 1993·Nature·G D PlowmanS Buckley
Jul 1, 1994·Proceedings of the Society for Experimental Biology and Medicine·N Ben-Baruch, Y Yarden
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A Orr-UrtregerY Yarden
Apr 1, 1994·Molecular and Cellular Biology·C E DabrowskiP A Schaffer
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·D Meyer, C Birchmeier
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G D PlowmanM Shoyab
Jan 1, 1993·Annual Review of Biochemistry·J Massagué, A Pandiella
Nov 1, 1995·Pflügers Archiv : European journal of physiology·M Juusola, A S French
Mar 1, 1996·Pflügers Archiv : European journal of physiology·J M Mienville, J L Barker
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·R KramerL E Theill

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Citations

May 15, 2008·Nature Reviews. Neuroscience·Lin Mei, Wen-Cheng Xiong
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·J S CameronS E Dryer
Oct 13, 2009·Autonomic Neuroscience : Basic & Clinical·K N Cane, C R Anderson
Sep 15, 2009·Autonomic Neuroscience : Basic & Clinical·Jason A Luther, Susan J Birren
May 2, 2002·The Journal of Comparative Neurology·Rebecca L AndersonIan L Gibbins
Jun 16, 2005·Journal of Neuroscience Research·Xin WangYan-Ai Mei
Sep 24, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Richard J Pearson, Steven L Carroll

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