Neurite outgrowth in normal and injured primary sensory neurons reveals different regulation by nerve growth factor (NGF) and artemin

Molecular and Cellular Neurosciences
Agnes W WongPeregrine B Osborne

Abstract

Neurotrophic factors have been intensively studied as potential therapeutic agents for promoting neural regeneration and functional recovery after nerve injury. Artemin is a member of the glial cell line-derived neurotrophic factor (GDNF) family of ligands (GFLs) that forms a signalling complex with GFRα3 and the tyrosine kinase Ret. Systemic administration of artemin in rodents is reported to facilitate regeneration of primary sensory neurons following axotomy, improve recovery of sensory function, and reduce sensory hypersensitivity that is a cause of pain. However, the biological mechanisms that underlie these effects are mostly unknown. This study has investigated the biological significance of the colocalisation of GFRα3 with TrkA (neurotrophin receptor for nerve growth factor [NGF]) in the peptidergic type of unmyelinated (C-fibre) sensory neurons in rat dorsal root ganglia (DRG). In vitro neurite outgrowth assays were used to study the effects of artemin and NGF by comparing DRG neurons that were previously uninjured, or were axotomised in vivo by transecting a visceral or somatic peripheral nerve. We found that artemin could facilitate neurite initiation but in comparison to NGF had low efficacy for facilitating neurite...Continue Reading

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Citations

Dec 19, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Neta ZilonyEster Segal
Mar 12, 2019·Frontiers in Molecular Neuroscience·Mirolyuba IlievaTanja Maria Michel
Jul 28, 2020·International Journal of Molecular Sciences·Mary Ann SteppCintia S de Paiva
Nov 26, 2020·Cellular and Molecular Neurobiology·Zhenzhen XuRenshi Xu

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