Neuritogenic and neuroprotective properties of peptide agonists of the fibroblast growth factor receptor.

International Journal of Molecular Sciences
Shizhong LiVladimir Berezin

Abstract

Fibroblast growth factor receptors (FGFRs) interact with their cognate ligands, FGFs, and with a number of cell adhesion molecules (CAMs), such as the neural cell adhesion molecule (NCAM), mediating a wide range of events during the development and maintenance of the nervous system. Determination of protein structure, in silico modeling and biological studies have recently resulted in the identification of FGFR binding peptides derived from various FGFs and NCAM mimicking the effects of these molecules with regard to their neuritogenic and neuroprotective properties. This review focuses on recently developed functional peptide agonists of FGFR with possible therapeutic potential.

References

Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J D ZhangS R Sprang
Jan 1, 1989·Annual Review of Biochemistry·W H Burgess, T Maciag
Oct 1, 1974·Journal of Neurochemistry·O S Jorgensen, E Bock
Feb 1, 1994·Current Opinion in Neurobiology·P Doherty, F S Walsh
Jun 21, 1996·The Journal of Biological Chemistry·D M OrnitzM Goldfarb
Jul 1, 1996·Nature Structural Biology·N K ThomsenF M Poulsen
Jan 1, 1997·Molecular and Cellular Neurosciences·H CremerA Represa
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·H CremerP M Lledo
Sep 18, 1999·Cell·A N PlotnikovM Mohammadi
Feb 2, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D M Ornitz
Mar 21, 2000·Journal of Neuroscience Research·A GarcèsO deLapeyrière
Apr 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·D MullerJ Z Kiss
May 10, 2000·Nature Structural Biology·C KasperI K Larsen
Jun 29, 2000·Biochemical and Biophysical Research Communications·F FioreD Birnbaum
Oct 6, 2000·Endocrine-related Cancer·C J PowersA Wellstein
Mar 29, 2001·Genome Biology·D M Ornitz, N Itoh
Feb 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Brian K YehMoosa Mohammadi
Jul 8, 2003·Cell and Tissue Research·Bernhard Reuss, Oliver von Bohlen und Halbach
Apr 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karine CambonCarmen Sandi
Sep 9, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Anders M HinsbyElisabeth Bock
Nov 20, 2004·Nature Reviews. Neuroscience·Carmen Sandi
Jan 25, 2005·Neurochemical Research·Peter S WalmodElisabeth Bock
May 3, 2005·Cytokine & Growth Factor Reviews·Moosa MohammadiOmar A Ibrahimi
May 3, 2005·Cytokine & Growth Factor Reviews·V P EswarakumarJ Schlessinger
May 3, 2005·Cytokine & Growth Factor Reviews·Lisa DaileyClaudio Basilico
Oct 4, 2005·The European Journal of Neuroscience·Galina G SkiboElisabeth Bock
May 20, 2006·FEBS Letters·Claus ChristensenVladislav V Kiselyov
Dec 7, 2007·Nature Reviews. Neuroscience·Urs Rutishauser

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Citations

Jul 31, 2012·Neurobiology of Disease·Maj N EnevoldsenElisabeth Bock
Oct 25, 2017·Journal of Cellular and Molecular Medicine·Yulong ZhouJian Xiao
Feb 13, 2019·Chemical Communications : Chem Comm·Ryosuke UekiShinsuke Sando
Feb 27, 2017·Journal of Molecular Neuroscience : MN·Giovanna MorelloSebastiano Cavallaro
Jul 14, 2018·Neurochemical Research·Chengyan ChuShen Li
Oct 23, 2019·Advances in Wound Care·Pinghui ZhouWenguo Cui

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Methods Mentioned

BETA
nuclear
X-ray
surface plasmon resonance
NMR
interaction studies

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