Neuritogenic effect of estradiol on rat ventromedial hypothalamic neurons co-cultured with homotopic or heterotopic glia

Journal of Neuroscience Research
M J CambiassoH F Carrer

Abstract

In sexually segregated cultures of dissociated neurons taken from ventromedial hypothalamus of rat fetuses at embryonic day 16 (E16), it is demonstrated that only neurons from males respond with increased axonal growth to the addition of 17-beta-estradiol 100 nM (E2) to the culture medium. Moreover, this response is contingent upon co-culture with heterotopic glia from a target region (amygdala), whereas in the presence of homotopic glia or in cultures without glia, E2 has no effect. It is concluded that before neurons are exposed to gonadal steroids in utero there is a sexual difference in the response to E2, probably explained by earlier maturation of neurons from males as compared to females. The possibility that the observed axogenic effect may be the consequence of an interaction among E2, cells equipped with specific receptors, and glia-producing trophic factors is discussed.

References

Oct 1, 1992·Neurochemistry International·B Oderfeld-NowakL Aloe
Sep 8, 1992·The Journal of Comparative Neurology·W OvtscharoffC Pilgrim
Nov 1, 1992·Journal of Neuroscience Research·A LorenzoA Cáceres
Jul 1, 1992·Molecular Reproduction and Development·B AveryT Greve
Aug 1, 1992·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C Pilgrim, I Reisert
Jan 1, 1991·Advances in Experimental Medicine and Biology·A Manolova, S Manolov
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S CeccatelliT Hökfelt
Jan 1, 1989·Neuroscience·G OlmosL M Garcia-Segura
Feb 1, 1989·Cell and Tissue Research·I ReisertC Pilgrim
Nov 1, 1988·Brain Research. Developmental Brain Research·R E WatsonG E Hoffman
Dec 1, 1985·Hormones and Behavior·A P Arnold, S M Breedlove
Jan 1, 1984·Annals of the New York Academy of Sciences·C D Toran-Allerand
Mar 1, 1995·Journal of Neuroscience Research·J Garcia-AbreuL A Cavalcante
Dec 1, 1994·Hormones and Behavior·R C MirandaD Toran-Allerand
Oct 1, 1994·Progress in Neurobiology·L M García-SeguraF Naftolin
Jan 1, 1994·Psychoneuroendocrinology·M M McCarthy
Jan 1, 1994·Psychoneuroendocrinology·L M Garcia-SeguraF Naftolin
Jan 1, 1994·Psychoneuroendocrinology·J B Hutchison, C Beyer
Dec 1, 1993·Neuroendocrinology·C BeyerJ B Hutchison

❮ Previous
Next ❯

Citations

Dec 18, 2001·Journal of Neuroscience Research·M J Cambiasso, H F Carrer
Jan 2, 1997·Brain Research. Developmental Brain Research·C Beyer, J B Hutchison
Mar 3, 2004·Annals of the New York Academy of Sciences·H F CarrerS Gorosito
Apr 30, 2005·The Journal of Steroid Biochemistry and Molecular Biology·H F CarrerS Gorosito
Jul 30, 2014·Frontiers in Cellular Neuroscience·María J ScerboMaría J Cambiasso
Jun 17, 2016·Journal of Neuroendocrinology·M F RossettiR Cabrera
Nov 22, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Florencia M DadamLaura Vivas
Mar 7, 2020·British Journal of Pharmacology·Franco R MirMaría Julia Cambiasso
Apr 20, 2019·Frontiers in Cellular Neuroscience·Lucas E Cabrera ZapataMaría Julia Cambiasso
Nov 27, 2016·The European Journal of Neuroscience·Franco R MirMaría J Cambiasso
Oct 12, 2021·Cellular and Molecular Life Sciences : CMLS·Lucas E Cabrera ZapataMaría Julia Cambiasso

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.