PMID: 7521858Jan 1, 1994Paper

Neuritogenic Lewis rat T cells use Tcrb chains that include a new Tcrb-V8 family member

Immunogenetics
X M ZhangE Heber-Katz

Abstract

The P2 protein obtained from Schwann cells induces a population of T cells which, upon adoptive transfer, causes the disease experimental allergic neuritis (EAN), an animal model for Guillain-Barre syndrome. In this report, a truncated peptide, FR22, derived from a previously reported neuritogenic T-cell determinant, was used to generate from Lewis rats T cells that were shown to cause EAN. Since our previous studies showed that Tcrb-V8 was used by a majority of T-cell hybridomas specific for the neuritogenic peptide P26, which contains the FR22 sequence, we sequenced the Tcrb-V8+ mRNA from FR22-specific T-cell lines, and compared the sequences obtained with those obtained from similarly generated myelin basic protein (MBP) 68-88-specific Lewis rat T-cell lines. We found that in the EAN lines, several members of the Tcrb-V8 family were used, including a new family member, Tcrb-V8E. This was more diverse than the MBP-68-88-specific response in which only a single Tcrb-V8 family member was used. Also, in the EAN lines, the beta chain sequences did not show the same conserved junctional regions seen in the MBP lines. Thus, T-cell receptor beta chain usage in the response to this dominant neuritogenic peptide appears to be less res...Continue Reading

References

Jan 1, 1991·Clinical Immunology and Immunopathology·D S GregersonE Heber-Katz
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R JoresT Meo
Feb 1, 1988·The Journal of Experimental Medicine·M P Happ, E Heber-Katz
Aug 1, 1988·Journal of Neuroimmunology·T OleeS W Brostoff
Feb 1, 1989·European Journal of Immunology·J ChlubaJ T Epplen
Apr 1, 1985·Cellular Immunology·A RostamiD E Pleasure
May 1, 1989·Immunology Today·E Heber-Katz, H Acha-Orbea
Jan 1, 1987·Methods in Enzymology·J Vieira, J Messing
Jul 1, 1974·The Biochemical Journal·P R Dunkley, P R Carnegie
Dec 1, 1984·Annals of Neurology·A RostamiD E Pleasure

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Citations

Jan 1, 1996·Springer Seminars in Immunopathology·H P HartungG Giegerich
Feb 12, 1997·Journal of the Neurological Sciences·A Khalili-ShiraziJ S Lanchbury
Jun 28, 2015·The Journal of Infectious Diseases·Ellen Heber-Katz
Mar 23, 1999·The Annals of Otology, Rhinology, and Laryngology·H MatsuokaT J Yoo

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