Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats

Neuropharmacology
Brandon J HallEdward D Levin

Abstract

Dopaminergic signaling has long been known to be a critical factor in nicotine addiction, as well as other drugs of abuse. Dopaminergic projections from the VTA to the nucleus accumbens and prefrontal cortex have been well established to be critical to the reinforcing effects of these drugs. However, other projections of dopamine neurons are likely to have significant roles in this process. Also, the relative contributions of D1 and D2 dopamine receptors in drug addiction and its treatment remain to be fully understood. In this study, we examined the effects of blocking D1 and D2 receptors in the nucleus accumbens shell (AcS), anterior cingulate cortex (ACC), and parietal association cortex (PtA) on nicotine self-administration in rats. Female Sprague-Dawley rats were fitted with jugular catheters and allowed to self-administer nicotine (0.03 mg/kg/infusion) on an FR1 schedule. Rats were fitted with bilateral infusion cannulae to allow infusion of D1 or D2 antagonists (SCH-23390 or haloperidol) into each targeted brain area. Acute local infusions of SCH-23390 (1-4 μg/side) into the AcS and PtA significantly reduced nicotine self-administration by up to 75%. SCH-23390 infusion into the ACC was less effective with only suggestive...Continue Reading

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Citations

Apr 25, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael J LacagninaStaci D Bilbo
Jun 13, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Edward D LevinAmir H Rezvani
May 28, 2019·Molecular Neurobiology·Gofarana WilarKohji Fukunaga
Nov 29, 2016·Frontiers in Cellular Neuroscience·Kari A Johnson, David M Lovinger

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