Neuro-Behçet disease presenting with internuclear ophthalmoplegia

American Journal of Ophthalmology
H MasaiH Fukuyama

Abstract

To report a case of isolated internuclear ophthalmoplegia in a patient with neuro-Behçet's disease. We evaluated the patient's clinical course. The patient had isolated internuclear ophthalmoplegia and headache. Subsequent cerebrospinal fluid study revealed marked pleocytosis predominated by lymphocytes (61%) and polymorphonuclear cells (35%), increased protein content, and normal glucose level. A magnetic resonance imaging study with T2-weighted image demonstrated a hyperintense area in the medial longitudinal fasciculus. Colchicine treatment of neuro-Behçet's disease caused marked improvement in the symptoms in this case, and the midbrain lesion completely disappeared after treatment.

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