(Neuro-)endocrinology of epithelial hair follicle stem cells

Molecular and Cellular Endocrinology
Ralf PausStephan Tiede

Abstract

The hair follicle is a repository of different types of somatic stem cells. However, even though the hair follicle is both a prominent target organ and a potent, non-classical site of production and/or metabolism of numerous polypetide- and steroid hormones, neuropeptides, neurotransmitters and neurotrophins, the (neuro-)endocrine controls of hair follicle epithelial stem cell (HFeSC) biology remain to be systematically explored. Focussing on HFeSCs, we attempt here to offer a "roadmap through terra incognita" by listing key open questions, by exploring endocrinologically relevant HFeSC gene profiling and mouse genomics data, and by sketching several clinically relevant pathways via which systemic and/or locally generated (neuro-)endocrine signals might impact on HFeSC. Exemplarily, we discuss, e.g. the potential roles of glucocorticoid and vitamin D receptors, the hairless gene product, thymic hormones, bone morphogenic proteins (BMPs) and their antagonists, and Skg-3 in HFeSC biology. Furthermore, we elaborate on the potential role of nerve growth factor (NGF) and substance P-dependent neurogenic inflammation in HFeSC damage, and explore how neuroendocrine signals may influence the balance between maintenance and destruction ...Continue Reading

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Citations

Nov 27, 2010·Pigment Cell & Melanoma Research·Ralf Paus
Dec 18, 2008·Genetics·Daniela Drummond-Barbosa
May 10, 2008·Molecular and Cellular Endocrinology·Neil A Hanley
May 20, 2015·Steroids·Andrzej T SlominskiRobert C Tuckey
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Jan 28, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuval RamotRalf Paus
Sep 19, 2020·Experimental Dermatology·Stefanie Heilmann-HeimbachMarkus M Nöthen

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