Neuro-glial neurotrophic interaction in the S-100 beta retarded mutant mouse (Polydactyly Nagoya). III. Transplantation study

Brain Research
S UedaE C Azmitia

Abstract

The hippocampus and caudo-dorsal cortex of the homozygote of polydactyly mutant mouse (Polydactyly Nagoya, Pdn/Pdn) were markedly reduced in S-100 beta positive astrocytes and serotonergic fibers as compared to the heterozygote (Pdn/+) and wild type (+/+) [39]. The Pdn/Pdn mice die within 2 days after birth, so it is impossible to examine postnatal changes. To demonstrate the developmental change of Pdn/Pdn hippocampal tissue, we transplanted hippocampal pieces of neonatal Pdn/Pdn and +/+ mice into the right and left hippocampus of the same adult +/+ mice, respectively, and immunocytochemically examined them. Two weeks after transplantation, +/+ hippocampal tissue contained a large number of glial fibrillary acidic protein (GFAP) and S-100 beta positive astrocytes and a number of serotonergic fibers. While Pdn/Pdn hippocampal tissue contained numerous GFAP positive astrocytes, S-100 beta positive astrocytes and serotonergic fibers were not observed. Two months after transplantation, GFAP and S-100 beta were expressed in the Pdn/Pdn hippocampal tissue similar to the +/+ tissue. Serotonergic fibers were distributed in the +/+ tissue, while no serotonergic fibers were observed in the Pdn/Pdn transplant tissue. In contrast, no diff...Continue Reading

References

Feb 1, 1979·Canadian Journal of Physiology and Pharmacology·L HertzA Schousboe
Jul 1, 1992·Journal of Chemical Neuroanatomy·E C AzmitiaD R Marshak
Jul 1, 1992·Journal of Chemical Neuroanatomy·R P HellendallJ M Lauder
Aug 1, 1991·Trends in Neurosciences·A Björklund
Jan 1, 1991·Advances in Anatomy, Embryology, and Cell Biology·K Y Reznikov
May 21, 1990·Brain Research·E C AzmitiaP M Whitaker-Azmitia
Feb 1, 1990·Brain Research. Developmental Brain Research·G Le PrinceM Tardy
Oct 1, 1989·Trends in Neurosciences·D D O'Leary
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J K ParkF F Ebner
Nov 1, 1988·Trends in Biochemical Sciences·D Kligman, D C Hilt
Jul 8, 1988·Science·P Rakic
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D Kligman, D R Marshak
Sep 21, 1984·Science·W M CowanB B Stanfield
Nov 10, 1981·The Journal of Comparative Neurology·A R Harvey, R D Lund
May 1, 1995·The Journal of Comparative Neurology·N M KheckE C Azmitia
Apr 1, 1995·Brain Research. Molecular Brain Research·S UedaE C Azmitia
Apr 15, 1994·Brain Research. Developmental Brain Research·H KeinoI Naruse

❮ Previous
Next ❯

Citations

Feb 12, 2009·Neurochemical Research·M I NogueiraE C Azmitia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.