Neuro-imaging findings in infants with congenital cytomegalovirus infection: relation to trimester of infection

Neonatology
Natanja OosteromLinda S de Vries

Abstract

Congenital cytomegalovirus (cCMV) infection early in pregnancy may result in major disabilities. Cerebral abnormalities detected using cranial ultrasound (cUS) and magnetic resonance imaging (MRI) have been related to neurological sequelae. To evaluate the additional value of MRI and assess the relationship between time of infection during pregnancy and outcome in infants with cCMV infection. Demographic and clinical data were collected in infants with cCMV infection (1992-2013). Trimester of infection, neuro-imaging results and outcome were reviewed. Cerebral abnormalities were categorized into none, mild (lenticulostriate vasculopathy, germinolytic cysts, high signal intensity on T2-weighted images) and severe (migrational disorder, ventriculomegaly, cerebellar hypoplasia). Results were statistically analysed. Thirty-six infants were eligible for analysis. cUS was performed in all and cranial MRI in 20 infants. Migrational disorders were only diagnosed using MRI (p < 0.01). In 17 infants trimester of infection was ascertained. Seven out of 10 infants infected during the first trimester had severe abnormalities on cUS (5 confirmed on MRI) and adverse sequelae; 3 had no/mild abnormalities on cUS/MRI and normal outcome. Two out ...Continue Reading

Citations

Jun 23, 2015·Journal de gynécologie, obstétrique et biologie de la reproduction·J CarraraO Picone
May 18, 2016·Seminars in Fetal & Neonatal Medicine·Thangamadhan Bosemani, Andrea Poretti
Jul 18, 2016·Neuroimaging Clinics of North America·Andrea PorettiThierry A G M Huisman
Apr 17, 2017·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Antonietta GiannattasioFrancesco Raimondi
Sep 18, 2018·The Pediatric Infectious Disease Journal·Antonietta GiannattasioFrancesco Raimondi
Aug 23, 2019·Chinese Medical Journal·Xin-Yan Zhang, Feng Fang
May 18, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Giulia LucignaniDaniela Longo
Aug 9, 2019·Biomedical Informatics Insights·Bernard Friedenson
Aug 10, 2020·Ear and Hearing·Laura CraeghsIngeborg Dhooge
May 1, 2021·Ear and Hearing·Bénédicte VosElizabeth M Fitzpatrick

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