Neuro-immune pathobiology of infectious enteric disease

Advances in Experimental Medicine and Biology
R A Argenzio

Abstract

Recent knowledge of neuro-endocrine-immune communication in the intestinal mucosa has provided a new paradigm for the pathophysiology of diarrheal disease that will significantly alter and advance therapeutic strategies. Mast cells, enteroendocrine cells and phagocytes are the proximate mediators of signalling cascades activated by parasitic nematodes and food allergens, enterotoxigenic bacteria, and at least some of the invasive pathogens, respectively. These proximate, trigger cells give rise to products that affect epithelial function directly, or indirectly through stimulation of prostaglandin production by mesenchymal cells, and enteric nerve stimulation, which can markedly amplify the initial stimulus. The enteric nervous system in fact may mediate the majority of the secretory response induced by enterotoxins or phagocytes. The signalling network mediated by cells in the lamina propria provides new points of control for pharmacological therapy.

Citations

Sep 24, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Zuberoa MarcosLaura Guembe
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anneke RijnierseAletta D Kraneveld
Nov 26, 2010·Journal of Neurogastroenterology and Motility·Oscar Rodríguez-FandiñoMax Schmulson
Aug 28, 2007·Pharmacology & Therapeutics·Anneke RijnierseAletta D Kraneveld

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