Neuro-nutrients as anti-alzheimer's disease agents: A critical review

Critical Reviews in Food Science and Nutrition
Sunil K RaviBruno Vincent

Abstract

Alzheimer's disease (AD) is characterized by a massive neuronal death causing memory loss, cognitive impairment and behavioral alteration that ultimately lead to dementia and death. AD is a multi-factorial pathology controlled by molecular events such as oxidative stress, protein aggregation, mitochondrial dysfunction and neuro inflammation. Nowadays, there is no efficient disease-modifying treatment for AD and epidemiological studies have suggested that diet and nutrition have a significant impact on the development of this disorder. Indeed, some nutrients can protect all kind of cells, including neurons. As prevention is better than cure, life style improvement, with a special emphasis on diet, should seriously be considered as an anti-AD track and intake of nutrients promoting neuronal health is the need of the hour. Diets rich in unsaturated fatty acids, polyphenols and vitamins have been shown to protect against AD, whereas saturated fatty acids-containing diets deprived of polyphenols promote the development of the disease. Thus, Mediterranean diets, mainly composed of fruits, vegetables and omega-3 fatty acids, stand as valuable, mild and preventive anti-AD agents. This review focuses on our current knowledge in the fiel...Continue Reading

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Citations

Oct 1, 2019·Oxidative Medicine and Cellular Longevity·Anna Laura CremoniniFiammetta Monacelli
Oct 8, 2020·Nutritional Neuroscience·Francesco VisioliEmma Burgos-Ramos
Sep 27, 2020·Progress in Lipid Research·Paolo AbresciaPaolo Bergamo
Apr 30, 2021·Expert Review of Neurotherapeutics·Marjan TalebiSaeed Samarghandian
May 13, 2021·Neuropsychiatric Disease and Treatment·Tamas FulopJacek M Witkowski
Mar 1, 2019·The Journal of Physical Chemistry. B·Yan LuPhilippe Derreumaux

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