Neuro-toxic and Reproductive Effects of BPA

Current Neuropharmacology
Antonietta SantoroRosaria Meccariello

Abstract

Bisphenol A (BPA) is one of the highest volume chemicals produced worldwide. It has recognized activity as an endocrine-disrupting chemical and has suspected roles as a neurological and reproductive toxicant. It interferes in steroid signaling, induces oxidative stress, and affects gene expression epigenetically. Gestational, perinatal and neonatal exposures to BPA affect developmental processes, including brain development and gametogenesis, with consequences on brain functions, behavior, and fertility. This review critically analyzes recent findings on the neuro-toxic and reproductive effects of BPA (and its analogues), with focus on neuronal differentiation, synaptic plasticity, glia and microglia activity, cognitive functions, and the central and local control of reproduction. BPA has potential human health hazard associated with gestational, peri- and neonatal exposure. Beginning with BPA's disposition, this review summarizes recent findings on the neurotoxicity of BPA and its analogues, on neuronal differentiation, synaptic plasticity, neuroinflammation, neuro-degeneration, and impairment of cognitive abilities. Furthermore, it reports the recent findings on the activity of BPA along the HPG axis, effects on the hypothala...Continue Reading

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Citations

Feb 13, 2020·International Journal of Molecular Sciences·Rosaria MeccarielloRiccardo Pierantoni
Jul 23, 2020·Toxicology and Industrial Health·Işil AydemirMehmet İbrahim Tuğlu
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Feb 13, 2021·International Journal of Environmental Research and Public Health·Stefania D'AngeloRosaria Meccariello
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Jan 23, 2021·International Journal of Molecular Sciences·Antonietta SantoroRosaria Meccariello
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Sep 21, 2020·General and Comparative Endocrinology·Rosaria MeccarielloRiccardo Pierantoni
Apr 4, 2021·International Journal of Environmental Research and Public Health·Stefania D'Angelo, Rosaria Meccariello
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Nov 28, 2021·International Journal of Molecular Sciences·Marianna MarinoAntonietta Santoro

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Methods Mentioned

BETA
nuclear translocation
acetylation

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