Neuroactive Steroid Levels in a transgenic rat model of CMT1A Neuropathy

Journal of Molecular Neuroscience : MN
Donatella CarusoR C Melcangi

Abstract

Charcot-Marie-Tooth type 1A (CMT1A) represents 80% of all the demyelinating hereditary motor and sensory neuropathies. As recently suggested, neuroactive steroids may have a role in a therapeutic strategy for peripheral neuropathies, including CMT1A. To this aim, an accurate qualitative and quantitative analysis of neuroactive steroid levels in this disease could be extremely important to define effective pharmacological strategies. We here analyzed by liquid chromatography-tandem mass spectrometry the levels of neuroactive steroids present in the sciatic nerve of male and female peripheral myelin protein 22 transgenic rats (PMP22(tg) rats; i.e., an experimental model of CMT1A) and of the corresponding wild-type littermates. We observed that, both in PMP22(tg) rats and in the wild types, the levels of neuroactive steroids, such as progesterone, tetrahydroprogesterone (THP), isopregnanolone (3beta,5alpha-THP), testosterone, dihydrotestosterone, and 5alpha-androstane-3alpha, 17beta-diol (3alpha-diol) are sexually dimorphic. It is interesting to note that the levels of 3beta,5alpha-THP and of 3alpha-diol, which are exclusively detectable in sciatic nerve of female and male rats, respectively, are strongly decreased in PMP22(tg) ra...Continue Reading

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Citations

Oct 15, 2013·Progress in Neurobiology·Roberto Cosimo Melcangi, Gian Carlo Panzica
Aug 25, 2015·Reviews in Endocrine & Metabolic Disorders·Abdulmaged M TraishMichael Zitzmann
Dec 4, 2009·Psychoneuroendocrinology·Roberto Cosimo Melcangi, Giancarlo Panzica
Dec 15, 2015·Neuroscience and Biobehavioral Reviews·Roberto C MelcangiLuis M Garcia-Segura
Jun 16, 2009·Hormones and Behavior·Roberto Cosimo Melcangi, Luis Miguel Garcia-Segura
May 9, 2009·Hormones and Behavior·Marzia PesaresiRoberto Cosimo Melcangi
Apr 1, 2015·Steroids·Silvia GiattiRoberto C Melcangi
Dec 23, 2011·Journal of Neuroendocrinology·G C PanzicaR C Melcangi
Jun 5, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G M Gargiulo-MonachelliM J Strong
Dec 1, 2009·Journal of Neurochemistry·Valerio MagnaghiFabio Fumagalli
Mar 24, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Silvia GiattiRoberto Cosimo Melcangi
Nov 20, 2013·Journal of the Neurological Sciences·Cécile ColombanShahram Attarian
Mar 7, 2012·The Quarterly Journal of Experimental Psychology : QJEP·Melanie Vitkovitch, Elisa Cooper
Jun 19, 2020·Journal of Medical Biochemistry·Milan B LakočevićMilan S Petakov
Dec 2, 2020·International Journal of Molecular Sciences·Eva FalvoSilvia Giatti

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