Neuroactive steroids: A therapeutic approach to maintain peripheral nerve integrity during neurodegenerative events.

Journal of Molecular Neuroscience : MN
Emanuela LeonelliRoberto C Melcangi

Abstract

It is now well known that peripheral nerves are a target for the action of neuroactive steroids. This review summarizes observations obtained so far, indicating that through the interaction with classical and nonclassical steroid receptors, neuroactive steroids (e.g., progesterone, testosterone and their derivatives, estrogens, etc.) are able to influence several parameters of the peripheral nervous system, particularly its glial compartment (i.e., Schwann cells). Interestingly, some of these neuroactive steroids might be considered as promising neuroprotective agents. They are able to counteract neurodegenerative events of rat peripheral nerves occurring after experimental physical trauma, during the aging process, or in hereditary demyelinating diseases. On this basis, the hypothesis that neuroactive steroids might represent a new therapeutic strategy for peripheral neuropathy is proposed.

Citations

Aug 8, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bai-Yan LiJohn H Schild
Mar 10, 2009·Pakistan Journal of Biological Sciences : PJBS·H R SameniM Makvandi
Aug 9, 2006·Expert Review of Neurotherapeutics·Roberto C Melcangi, Luis M Garcia-Segura
Apr 1, 2008·Molecular and Cellular Biochemistry·Thant S Zhu, Michael Glaser
Jan 1, 2010·Hormone Molecular Biology and Clinical Investigation·Laura GarayAlejandro F De Nicola
Nov 14, 2020·Biology of Sex Differences·Katja Linher-MelvilleGurmit Singh
May 27, 2020·Developmental Cognitive Neuroscience·Tiffany C HoIan H Gotlib
Dec 6, 2006·The Urologic Clinics of North America·Deborah R Erickson, Kathleen J Propert

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