Neuroactive Steroids and Affective Symptoms in Women Across the Weight Spectrum

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Laura E DichtelKaren K Miller

Abstract

3α-5α-Tetrahydroprogesterone, a progesterone metabolite also known as allopregnanolone, and 5α-androstane-3α,17β-diol, a testosterone metabolite also known as 3α-androstanediol, are neuroactive steroids and positive GABAA receptor allosteric modulators. Both anorexia nervosa (AN) and obesity are complicated by affective comorbidities and hypothalamic-pituitary-gonadal dysregulation. However, it is not known whether neuroactive steroid levels are abnormal at the extremes of the weight spectrum. We hypothesized that serum allopregnanolone and 3α-androstanediol levels would be decreased in AN compared with healthy controls (HC) and negatively associated with affective symptoms throughout the weight spectrum, independent of body mass index (BMI). Thirty-six women were 1 : 1 age-matched across three groups: AN, HC, and overweight/obese (OW/OB). AN were amenorrheic; HC and OW/OB were studied in the follicular phase. Fasting serum neuroactive steroids were measured by gas chromatography/mass spectrometry. Mean Hamilton depression and anxiety scores were highest in AN (p<0.0001). Mean serum allopregnanolone was lower in AN and OW/OB than HC (AN 95.3±56.4 vs OW/OB 73.8±31.3 vs HC 199.5±167.8 pg/ml, p=0.01), despite comparable mean serum...Continue Reading

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Citations

Jun 28, 2019·Frontiers in Behavioral Neuroscience·Graziano Pinna
Nov 6, 2018·Expert Review of Proteomics·Dario Aspesi, Graziano Pinna
Jun 21, 2019·The Journal of Clinical Endocrinology and Metabolism·Allison KimballKaren K Miller
Apr 5, 2018·Psychopharmacology·Tomoyuki Kawada
Aug 23, 2018·Frontiers in Neuroscience·Graziano Pinna
Feb 12, 2019·Behavioural Pharmacology·Dario Aspesi, Graziano Pinna
Apr 2, 2021·The Journal of Clinical Endocrinology and Metabolism·Melanie H JacobsonLeonardo Trasande
Jul 1, 2021·Journal of Neuroendocrinology·Silvia DiviccaroRoberto Cosimo Melcangi
Nov 4, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sik Yu So, Tor C Savidge

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JMP Pro Database
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