Neuroanatomic relationships between the GABAergic and serotonergic systems in the developing human medulla.

Autonomic Neuroscience : Basic & Clinical
Kevin G BroadbeltHannah C Kinney

Abstract

gamma-Amino butyric (GABA) critically influences serotonergic (5-HT) neurons in the raphé and extra-raphé of the medulla oblongata. In this study we hypothesize that there are marked changes in the developmental profile of markers of the human medullary GABAergic system relative to the 5-HT system in early life. We used single- and double-label immunocytochemistry and tissue receptor autoradiography in 15 human medullae from fetal and infant cases ranging from 15 gestational weeks to 10 postnatal months, and compared our findings with an extensive 5-HT-related database in our laboratory. In the raphé obscurus, we identified two subsets of GABAergic neurons using glutamic acid decarboxylase (GAD65/67) immunostaining: one comprised of small, round neurons; the other, medium, spindle-shaped neurons. In three term medullae cases, positive immunofluorescent neurons for both tryptophan hydroxylase and GAD65/67 were counted within the raphé obscurus. This revealed that approximately 6% of the total neurons counted in this nucleus expressed both GAD65/67 and TPOH suggesting co-production of GABA by a subset of 5-HT neurons. The distribution of GABA(A) binding was ubiquitous across medullary nuclei, with highest binding in the raphé obs...Continue Reading

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Citations

Oct 5, 2012·Nature·Nicolas X TritschBernardo L Sabatini
Dec 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Rémi BosLaurent Vinay
Sep 23, 2011·Journal of Neuropathology and Experimental Neurology·Gang XuHannah C Kinney
Aug 26, 2011·Journal of Neuropathology and Experimental Neurology·Kevin G BroadbeltHannah C Kinney
Oct 18, 2013·Neuropathology and Applied Neurobiology·Simon M L PaineNeil J Sebire
Oct 7, 2015·Frontiers in Neuroanatomy·Rosa M VillalbaYoland Smith
Aug 4, 2015·Environmental Toxicology and Pharmacology·Kamilla Blecharz-KlinEwa Widy-Tyszkiewicz
Sep 3, 2018·Reviews in the Neurosciences·Fabiola Hernández-VázquezSalvador Hernández-López
Jan 16, 2014·Journal of Neuropathology and Experimental Neurology·Ingvar J RognumHannah C Kinney
Aug 10, 2019·Journal of Neuropathology and Experimental Neurology·Hannah C Kinney, Robin L Haynes
Jun 11, 2015·Physiological Reports·Chrystelle M SirieixRobert A Darnall

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