Neuroanatomical and neuropsychological features of euthymic patients with bipolar disorder

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Christophe DelaloyeGabriel Gold

Abstract

Previous studies reported that the severity of cognitive deficits in euthymic patients with bipolar disorder (BD) increases with the duration of illness and postulated that progressive neuronal loss or shrinkage and white matter changes may be at the origin of this phenomenon. To explore this issue, the authors performed a case-control study including detailed neuropsychological and magnetic resonance imaging analyses in 17 euthymic elderly patients with BD and 17 healthy individuals. Neuropsychological evaluation concerned working memory, episodic memory, processing speed, and executive functions. Volumetric estimates of the amygdala, hippocampus, entorhinal cortex, and anterior cingulate cortex were obtained using both voxel-based and region of interest morphometric methods. Periventricular and deep white matter were assessed semiquantitatively. Differences in cognitive performances and structural data between BD and comparison groups were analyzed using paired t-test or analysis of variance. Wilcoxon test was used in the absence of normal distribution. Compared with healthy individuals, patients with BD obtained significantly lower performances in processing speed, working memory, and episodic memory but not in executive fun...Continue Reading

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Citations

Aug 30, 2012·International Psychogeriatrics·Chanaka WijeratnePerminder S Sachdev
Dec 19, 2009·Journal of Affective Disorders·Kerstin WeberAlessandra Canuto
Nov 26, 2009·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Robert C Young, Kenneth I Shulman
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Sep 6, 2013·International Journal of Geriatric Psychiatry·Soham RejAriel Gildengers
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Nov 9, 2011·The Spanish Journal of Psychology·Silvana OliveiraClarissa Trentini
Mar 28, 2012·International Journal of Geriatric Psychiatry·Diego J MartinoFacundo Manes

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