Neuroanatomical Assessment of the Integrin β3 Mouse Model Related to Autism and the Serotonin System Using High Resolution MRI.

Frontiers in Psychiatry
Jacob EllegoodJason P Lerch

Abstract

The integrinβ3 (ITGβ3) gene has been associated with both autism and the serotonin system. The purpose of this study was to examine the volumetric differences in the brain of an ITGβ3 homozygous knockout mouse model compared with a corresponding wild-type mouse using high resolution magnetic resonance imaging and detailed statistical analyses. The most striking difference found was an 11% reduction in total brain volume. Moreover, 32 different regions were found to have significantly different relative volumes (percentage total brain volume) in the ITGβ3 mouse. A number of interesting differences relevant to autism were discovered including a smaller corpus callosum volume and bilateral decreases in the hippocampus, striatum, and cerebellum. Relative volume increases were also found in the frontal and parieto-temporal lobes as well as in the amygdala. Particularly intriguing were the changes in the lateral wings of the dorsal raphe nuclei since that nucleus is so integral to the development of many different brain regions and the serotonin system in general.

Citations

Mar 11, 2015·Autism Research : Official Journal of the International Society for Autism Research·Jacob EllegoodJason Lerch
Oct 24, 2013·Autism Research : Official Journal of the International Society for Autism Research·Patrick E SteadmanJason P Lerch
May 22, 2016·Neuropharmacology·Yvet KroezeJudith R Homberg
Nov 23, 2017·Frontiers in Molecular Neuroscience·Keren OvedNoam Shomron
Feb 13, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kamila U SzulcDaniel H Turnbull
Sep 4, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Hongen WeiXiaohong Li
Jun 22, 2018·Current Protocols in Mouse Biology·Brian J NiemanJason P Lerch
Jun 4, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jacob Ellegood, Jacqueline N Crawley
Nov 22, 2016·Journal of Neuroscience Research·Meng-Chuan LaiSimon Baron-Cohen
Feb 2, 2021·Frontiers in Cellular Neuroscience·Tanya Gandhi, Charles C Lee
Jan 16, 2021·Integrative Psychological & Behavioral Science·Raju Paudel, Shamsher Singh
Nov 19, 2021·Frontiers in Integrative Neuroscience·Ala SeifRyan A Stevenson

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