Neuroanatomical changes in white and grey matter after sleeve gastrectomy.

NeuroImage
Andréanne MichaudAlain Dagher

Abstract

MRI studies show that obese adults have reduced grey matter (GM) and white matter (WM) tissue density as well as altered WM integrity. Bariatric surgery can lead to substantial weight loss and improvements in metabolic parameters, but it remains to be examined if it induces structural brain changes. The aim of this study was to characterize GM and WM density changes measured with MRI in a longitudinal setting following sleeve gastrectomy, and to determine whether any changes are related to inflammation and cardiometabolic blood markers. 29 participants with obesity (age: 45.9 ​± ​7.8 years) scheduled to undergo sleeve gastrectomy were recruited. High-resolution T1-weighted anatomical images were acquired 1 month prior to as well as 4 and 12 months after surgery. GM and WM densities were quantified using voxel-based morphometry (VBM). Circulating lipid profile, glucose, insulin and inflammatory markers (interleukin-6, C-reactive protein and lipopolysaccharide-binding protein) were measured at each time point. A linear mixed effect model was used to compare brain changes before and after SG, controlling for age, sex, initial BMI and diabetic status. To assess the associations between changes in adiposity, metabolism and inflammat...Continue Reading

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Citations

Feb 19, 2021·Frontiers in Neuroscience·Laurent Gautron
Jul 25, 2021·NeuroImage·Yashar ZeighamiAndréanne Michaud
Jul 21, 2021·Neuroscience and Biobehavioral Reviews·Justine DaoustAndréanne Michaud
Jun 13, 2021·The Journal of Clinical Endocrinology and Metabolism·Alexandre Caron, Natalie Jane Michael

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