Neuroanatomical correlates of food addiction symptoms and body mass index in the general population

Human Brain Mapping
Frauke BeyerAnja Veronica Witte

Abstract

The food addiction model suggests neurobiological similarities between substance-related and addictive disorders and obesity. While structural brain differences have been consistently reported in these conditions, little is known about the neuroanatomical correlates of food addiction. We therefore aimed to determine whether symptoms of food addiction related to body mass index (BMI), personality, and brain structure in a large population-based sample. Participants of the LIFE-Adult study (n = 625; 20-59 years old, 45% women) answered the Yale Food Addiction Scale (YFAS) and further personality measures, underwent anthropometric assessments and high-resolution 3T-neuroimaging. A higher YFAS symptom score correlated with higher BMI, eating behavior traits, neuroticism, and stress. Higher BMI predicted significantly lower thickness of (pre)frontal, temporal and occipital cortex and increased volume of left nucleus accumbens. In a whole-brain analysis, YFAS symptom score was not associated with significant differences in cortical thickness or subcortical gray matter volumes. A hypothesis-driven Bayes factor analysis suggested a small, additional contribution of YFAS symptom score to lower right lateral orbitofrontal cortex thicknes...Continue Reading

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Citations

Nov 24, 2019·Journal of Neuroendocrinology·Isabel García-GarcíaAlain Dagher
Apr 9, 2020·Journal of Eating Disorders·Anne SchienleAlbert Wabnegger
Sep 25, 2020·Eating and Weight Disorders : EWD·Armando PiccinniCargioli Claudio
Oct 27, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Frauke BeyerA Veronica Witte
Mar 8, 2021·The Journal of Clinical Endocrinology and Metabolism·Filip MorysAlain Dagher

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