Neuroanatomical distribution of Huntingtin-associated protein 1-mRNA in the male mouse brain

The Journal of Comparative Neurology
Ryutaro FujinagaKoh Shinoda

Abstract

Huntingtin-associated protein 1 (HAP1) was identified as an interactor of the gene product (Huntingtin) responsible for Huntington's disease and found to be a core component of the stigmoid body. Even though HAP1 is highly expressed in the brain, detailed information on HAP1 distribution has not been fully described. Focusing on the neuroanatomical analysis of HAP1-mRNA expression using in situ hybridization histochemistry, the present study clarified its detailed regional distribution in the entire mouse brain. Mouse HAP1 (Hap1)-mRNAs were abundantly expressed in the limbic-related forebrain regions and midline/periventricular brainstem regions including the olfactory bulb, limbic-associated cortices, hippocampus, septum, amygdala, bed nucleus of the stria terminalis, preoptico-hypothalamic regions, central gray, raphe nuclei, locus coeruleus, parabrachial nuclei, nucleus of the solitary tract, and area postrema. In contrast, little expression was detected in the striatum and thalamus, implying that Hap1 is associated with neurodegeneration-sparing regions rather than target lesions in Huntington's disease. The distribution pattern, resembling that of the stigmoid body, suggests that HAP1 and the stigmoid body are implicated i...Continue Reading

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Citations

May 6, 2011·Cellular and Molecular Life Sciences : CMLS·Austin CapeXiao-Jiang Li
Apr 11, 2006·Nature Medicine·Guoqing ShengXiao-Jiang Li
Nov 11, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Min LiaoHe Li
Aug 10, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Min LiaoHe Li
Dec 15, 2010·FEBS Letters·Shao-Na NiuGuo-Qing Sheng
Dec 1, 2011·Neurobiology of Disease·Jean-Christophe RouxLaurent Villard
Jul 10, 2008·The Journal of Comparative Neurology·June KawanoKoh Shinoda
Jul 9, 2013·Neurobiology of Learning and Memory·Alexander C PartinJonathan E Ploski
Mar 6, 2009·Cell Adhesion & Migration·Linda Lin-yan Wu, Xin-Fu Zhou
Jun 26, 2020·Frontiers in Cellular Neuroscience·Xingxing ChenXiao-Jiang Li
Aug 5, 2020·Proceedings of the National Academy of Sciences of the United States of America·Qiong LiuXiao-Jiang Li

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